6 days ago · Polyclonal Antibody for studying TCRbeta. Validated for WB. Highly specific and rigorously validated in-house, TRBC1/TCRβ constant region 1 Antibody (CST #77046) is ready to ship.

4 days ago · T Cell Receptor (TCR) activation promotes a number of signaling cascades that ultimately determine cell fate through regulating cytokine production, cell survival, proliferation, and differentiation.

Here we highlight these recent findings, focusing on the proximal TCR signaling molecules Zap70, Lck, and LAT, to provide mechanistic models and insights into the exquisite sensitivity and specificity of the TCR.

Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28.

When a TCR engages a relevant pMHC ligand (or other stimulus such as anti-TCR crosslinking), TCR signaling is initiated (FIGURE 1B). Each clonally distributed TCR is sufficient for pMHC recognition, however, the associated invariant CD3 and ζ …

Aug 19, 2014 · Activation of T cells through the T cell antigen receptor (TCR) is essential for thymocyte development and effector T cell function. Identification of the signaling components and how their...

Phospho-Flow is a largely quantitative technology with excellent throughput, highly suited in studying the function or inhibition of TCR signaling pathways and allowing the detection of novel pathway insights. It can serve as a good complement to Western blot analysis.

T 细胞受体 (TCR) 激活可促进许多信号转导级联反应，通过调控细胞因子产物、细胞生存、增殖和分化来最终决定细胞命运。 TCR 激活的早期事件是由淋巴细胞蛋白质酪氨酸激酶 (Lck)，对 TCR/CD3 复合体胞质一侧的免疫受体酪氨酸依赖性活化基序 (ITAMs) 的磷酸化作用。

Jun 11, 2008 · We show here for the first time a side-by-side comparison of WB and Phospho-Flow to assess the signaling hierarchy of TCR phosphorylation events, their kinetics of phosphorylation and dephosphorylation as well as the sensitivity of TCR signaling pathways towards pharmacological kinase inhibitors.

T cell receptors (TCR) play a key role in functioning of T cells and formation of the immunological synapse. It provides connection between T cell and the antigen-presenting cell (APC).