Both transmembrane and cytoplasmic tyrosine phosphatases have been identified in T cells and shown to regulate T-cell responses. This review focuses on the roles of the two cytoplasmic …

These data highlight an unexpected and global role of SHP-1 in regulating CD8(+) T cell activation and responsiveness and support the development of therapies inhibiting protein …

We found that TCR stimulation induced fast (≤1min) and transient phosphorylation of SHP-1 S591 in both Jurkat and human peripheral blood T-cells (PBT).

Mar 1, 2013 · We describe how the inhibitory receptor programmed cell death-1 (PD-1) and the Src homology 2 domain–containing phosphatase 1 (SHP-1) are involved in restricting T cell …

Stimulation of the TCR leads to the SHP-1–mediated dephosphorylation of CrkII, which then travels from the c-SMAC to the p-SMAC. Here, CrkII binds to the exchange factor C3G, which …

Sep 15, 1999 · SHP-1 inhibitory effects on TCR-directed mitogenesis suggest that SHP-1 raises the threshold for TCR transmission of activation signals. Thus, this PTP is likely to act in …

We found that T cell receptor (TCR) stimulation induced fast (<or=1 min) and transient phosphorylation of SHP-1 S591 in both Jurkat and human peripheral blood T-cells (PBT).

Jan 2, 2024 · Its absence reduces T cell receptor (TCR) signaling and increases the interaction of the tyrosine phosphatase SHP-1, a major negative regulator of proximal TCR signaling, with …

May 15, 1999 · Our studies support a role for SHP-1 in TCR signal transduction and demonstrate the importance in regulating thymocyte development.

We found that TCR stimulation induced fast (≤1min) and transient phosphorylation of SHP-1 S591 in both Jurkat and human peripheral blood T-cells (PBT).