T-cell receptor (TCR) stimulation causes the dephosphorylation of NFAT which in almost every kind of T cell then forms a complex with AP-1 (except in Tregs). This complex depending on …

Jun 1, 2005 · In T cells, NFAT proteins are activated following T-cell receptor (TCR) ligation. Increases in calcium that are induced by TCR engagement activate calcineurin, which causes …

Functional endpoint measures of TCR stimulation are determined by measuring either cytokine productions (IFNγ or IL2) or measuring activation of a reporter construct driven by a Nuclear …

Pathway integration is further regulated temporally, where T cell receptor (TCR) and chimeric antigen recep-tor (CAR) activation signals modulate the temporal relationships between the …

Jun 23, 2023 · Here, we show that two key pathways in T cell signaling, calcium/nuclear factor of activated T cells (NFAT) and protein kinase C (PKC)/nuclear factor κB (NF-κB), integrate …

A cornerstone of the adaptive immune response is the T cell receptor (TcR)-calcium-calcineurin signalling pathway leading to T cell activation. The 'nuclear factor of activated T cells' proteins …

This study is the first to present an antigen specific reporter system for the evaluation of TCR signaling via NF-κB, NFAT and AP-1 using the Jurkat 76 T cell line.

Nef-mediated inhibition of NFAT signalling activity was assessed by transfecting the Nef clones into a Jurkat T cell line, stimulating the TCR with anti-CD3 antibody, and then measuring the …

Jul 25, 2023 · Here, we show that two key pathways in T cell signaling, calcium/nuclear factor of activated T cells (NFAT) and protein kinase C (PKC)/nuclear factor κB (NF-κB), integrate …

Feb 24, 2021 · T cell receptor (TCR) activation triggers phosphorylation of the kinase Lck, which in turn activates calcineurin pathways. Calcineurin dephosphorylates cytoplasmic nuclear …