The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, [1] that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.

Feb 26, 2025 · In this paper, we propose a unified deep framework (called UniPMT) for peptide, MHC and TCR binding prediction to predict the binding between the peptide and the CDR3 of TCR β in general,...

Dec 13, 2021 · Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells.

Aug 23, 2022 · Interactions between a T cell receptor (TCR) and a peptide-major histocompatibility complex (pMHC) ligand are typically mediated by noncovalent bonds. By studying T cells expressing natural or...

Jan 12, 2001 · The receptors on T cells, however, are restricted to sensing the presence of protein antigens by binding to short peptides from the antigens that are presented on the surface of other cells bound to class I or class II molecules of the major histocompatibility complex (MHC).

Jan 20, 2023 · The specificity of T cell receptors (TCR) for peptides presented by major histocompatibility complex proteins (pMHC) is a critical determinant of adaptive immune responses to pathogens and tumors and of autoimmune disease.

Jan 15, 2025 · Here, we present tFold-TCR, a high-throughput, end-to-end universal model for predicting three-dimensional (3D) atomic-level structures of TCR-pMHC complexes, capable of predicting TCRs of different classes and MHC structures from diverse systems. tFold-TCR leverages a specially trained, protein-protein interaction-sensitive large protein ...

T cells use their surface receptor, called T cell receptor or TCR, to recognise peptides presented by major histocompatibility complex (MHC) molecules. The peptide presented by MHC can be derived from the host proteins (self-peptides), pathogens (virus and bacteria), or tumours.

Dec 23, 2020 · The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR).

Dec 18, 2019 · Intracellular tumor-related antigens can be presented as peptides in the major histocompatibility complex (MHC) on the cell surface, which interact with the T cell receptors (TCR) on antigen-specific T cells to stimulate an anti-tumor response.