Apr 1, 2005 · In T cells, there is an added 'twist' in which ligation of the antigen receptor (TCR), particularly in the context of CD28 coligation, can activate p38 in nonstress conditions.

Dec 13, 2021 · Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated...

Nov 1, 1997 · During development, progenitor thymocytes differentiate into either CD4 or CD8 T cells, and this fate decision depends on the specificity of the T cell antigen receptor (TCR) for MHC class II or class I molecules.

Mar 15, 2016 · Targeted inhibition of mitogen-activated protein kinase (MAPK) kinase (MEK) can induce regression of tumors bearing activating mutations in the Ras pathway but rarely leads to tumor eradication.

In the present study we show that TCR-mediated MAPK activation suppresses CD95-mediated apoptosis during the early phase of T cell activation. This inhibition is protein synthesis independent and occurs after assembly of a functional DISC but before overall caspase-8 activation and cleavage of Bid.

As T cell receptor (TCR) stimulation can activate MAPK signaling (51), it is possible that STING can enhance this process, and the STING signaling can synergize with TCR to induce MAPK activation.

Feb 27, 2005 · Signaling-responsive MAP kinases (MAPKs) are key in mediating immune responses and are activated through the phosphorylation of a Thr-X-Tyr motif by upstream MAPK kinases.

Signalling through the IFNαR (interferon-α receptor) and TCR (T-cell receptor) in Jurkat T lymphocytes results in distinct immune responses. Despite this both receptors elicit ERK (extracellular-signal-regulated kinase)/MAPK (mitogen-activated protein kinase) phosphorylation.

In T lymphocytes, the mitogen-activated protein kinase (MAPK) p38 regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative activation pathway downstream of the T cell antigen receptor (TCR).

Jul 7, 2004 · Accumulating evidence suggests that MAPK family plays a pivotal role in regulating T-cell functions. JNK and p38 are synergistically activated by stimulation via T-cell receptor (TCR) and costimulatory molecule such as CD28, while ERK can be fully activated by engagement of the TCR alone (Su et al, 1994; Matsuda et al, 1998).