Tyrosin-protein kinase Lck - Wikipedia
Tyrosin-protein kinase Lck (or lymphocyte-specific protein tyrosine kinase) is a 56 kDa protein that is found inside lymphocytes and encoded in the human by the LCK gene. [5] The Lck is a …
Bound to be perfect: Lck and T cell co-receptors - Nature
Jan 3, 2023 · Interactions between the T cell co-receptors CD4 or CD8 and the kinase Lck safeguard T cell activation by low-affinity ligands. Meanwhile, ‘free’ Lck — which cannot bind …
LCK–co-receptor association ensures T cell lineage fidelity and ...
Feb 21, 2025 · In mice expressing mutated endogenous LCK unable to bind co-receptors (LCK FREE mice), we show that influenza A virus (IAV)–derived pMHC-specific CD8 and CD4 T cell …
Noncanonical binding of Lck to CD3ε promotes TCR signaling and …
Jul 20, 2020 · We report a previously unknown binding motif in the CD3ε cytoplasmic tail that interacts in a noncanonical mode with the Lck SH3 domain: the receptor kinase (RK) motif. …
Beyond TCR Signaling: Emerging Functions of Lck in Cancer and ...
In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck-deficient T …
T cell receptor (TCR) signaling in health and disease
Dec 13, 2021 · Interaction between coreceptors and LCK has two important functions: it brings LCK in close proximity to the TCR complex and it stabilizes coreceptors by preventing clathrin …
TCR Signaling: Mechanisms of Initiation and Propagation
Dec 18, 2017 · Lck is basally active and phosphorylates the TCR complex and Zap70 on pMHC binding. Active Lck abundance and its coupling to the TCR during antigen encounter are able …
How does the kinase Lck phosphorylate the T cell receptor?
TCR signaling is triggered by the recognition and engagement of antigenic peptides bound to major histocompatibility complex (MHC) and relies on the phosphorylation by Lck of receptor …
T cell development is regulated by the coordinated function of …
Lck is a T cell lineage-specific tyrosine kinase critical for T cell development and activation through its role in pre-TCR and TCR signaling. Expression of identical Lck protein can be …
Lck activation: puzzling the pieces together - PMC
Nov 11, 2017 · The Src-family kinase Lck is an essential regulator of T-cell functions (e.g. development, activation, and homeostasis), which is involved in the initiation of TCR signaling. …