The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, [1] that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.

T cell receptor (TCR) gene rearrangement is an important event in T cell ontogeny that enables T cells to recognise antigens specifically, and any dysregulation in this complex yet highly regulated process may result in disease.

Dec 13, 2021 · The human genome expresses four TCR genes known as TCRα, TCRβ, TCRγ, and TCRδ, which forms two distinct heterodimers: TCRα/TCRβ or TCRγ/TCRδ. 16, 17, 18 The majority of mature T cells ...

The somatic assembly of T cell receptor (TCR) genes (Tcra, Tcrb, Tcrg, Tcrd) generates a diverse T cell repertoire and is an essential component of thymocyte development that instructs numerous cell lineage and cell fate decisions.

Jan 8, 2021 · TCRdb contains more than 277 million highly reliable TCR sequences from over 8265 TCR-Seq samples across hundreds of tissues/clinical conditions/cell types.

Aug 29, 2024 · T cell receptors (TCRs) are crucial components of the adaptive immune system, enabling T cells to recognize and respond to specific antigens. The TCR’s role is pivotal in immune surveillance and defense against pathogens.

T-cell receptor (TCR) genes undergo somatic gene rearrangement resulting in a diversity of antigen binding capability among T-cells. The TCR is a heterodimeric protein consisting of highly variable α and ß chains (αß T-cells) or γ chains and δ chains (γδ T-cells).

Mar 13, 2025 · T cell receptor (TCR) diversity arises from TCR gene rearrangement, an orchestrated process in developing T cells within the thymus. This enables the formation of unique TCRs capable of recognizing a broad spectrum of antigens.

Jan 1, 2016 · The association of TCR either with Class I and Class II HLA gene products (MHC) augments the specificity of the TCR. The Class I HLA antigens are associated with the cytotoxic (killer) cells, whereas the helper lymphocytes attach to the Class II antigens.

Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28.