Apr 18, 2024 · Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune cells that inform on understanding immune cell...

Feb 24, 2025 · This review highlights key methodologies and considerations for TCR and BCR repertoire analysis, focusing on the technical aspects of receptor sequence extraction, data processing, and clonotype identification.

Jul 11, 2023 · The main difference between BCR and TCR is that BCR, or B cell receptor, binds directly to the antigen surface, whereas TCR, or T cell receptor, recognizes antigenic peptides with MHC molecules.

In this work, we developed spatial transcriptomics for variable, diversity, and joining (VDJ) sequences (Spatial VDJ), which maps full-length BCR and TCR transcripts in human tissue (Fig. 1A).

We review downstream analyses, including BCR and TCR epitope prediction, antibody-antigen docking and TCR-peptide-MHC Modeling. We also briefly discuss molecular dynamics in this context.

Dec 21, 2024 · Two key components of the immune system, B-cell receptors (BCRs) and T-cell receptors (TCRs), play distinct yet interconnected roles in recognizing pathogens. Sequencing the BCR and TCR repertoires provides deep insights into immune responses. But what exactly differentiates these two receptors?

Explore the differences between BCR vs TCR sequencing, including methods, diversity, and applications in immunology. Learn how these insights drive advanced therapies.

Bulk Immune Repertoire Sequencing: Explore the principles of TCR/BCR sequencing to understand immune diversity, disease resistance, and potential therapeutic applications.

scRepertoire defines clones as TCRs/BCRs with shared/trackable complementarity-determining region 3 (CDR3) sequences. You can define clones using the amino acid sequence (aa), nucleotide (nt), or the V (D)JC genes (genes).

We provide human TCR/BCR and mouse (C57BL/6 and BALB/c strains) BCR sequencing (we DO NOT offer mouse TCR sequencing). We also provide customized TCR/BCR sequencing to look at specific immune response (such as the NP response in mice).