CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). [1]

Aug 28, 2019 · In this study, we report a cryo-electron microscopy (cryo-EM) structure of a human TCR–CD3 complex in its unliganded state at 3.7 Å resolution. The structure reveals the mechanisms that...

Mar 12, 2025 · The TCR CD3 complex is a multi-subunit structure that facilitates antigen recognition and intracellular signaling in T cells. It consists of the antigen-binding TCR heterodimer, typically composed of α and β chains, and the CD3 signaling subunits: CD3γ, CD3δ, CD3ε, and the ζ-chain homodimer.

Apr 19, 2020 · TCR-CD3 complex majorly recognizes the Ag-MHC molecules and various other membrane molecule play important role in Ag recognition and T-cell activation. Some of these membrane molecules strengthen interaction between T cell and APC or target cells and some act in signal transduction and some do both.

We review evidence from single-molecule and structural studies for force-induced conformational changes in the TCR–CD3 complex, for dynamically-driven TCR allostery, and for pMHC-induced structural changes in the transmembrane and cytoplasmic regions of CD3 subunits.

Dec 13, 2021 · Signals from both the TCR-CD3 complex and co-stimulatory receptors, such as CD28, CD2, and the CD150/SLAM (signaling lymphocyte activation molecule) family, are required for full activation...

Apr 24, 2024 · These findings reveal organizing principles of the γδ TCR–CD3 complex, providing insights into the unique properties of γδ TCR and facilitating immunotherapeutic interventions.

The TCR/CD3 complex determines the specificity of the immune response and is the first signal needed to trigger T cell activation. The development of new approaches to modulate the activity of this complex is very attractive for immunotherapy.

The T cell receptor (TCR)–CD3 complex represents on of the most intricate membrane receptor structures since it is built from six distinct chains. This complexity led to a number of different proposals for the arrangement of the receptor subunits, ...

Jan 24, 2020 · We review evidence from single-molecule and structural studies for force-induced conformational changes in the TCR-CD3 complex, for dynamically-driven TCR allostery, and for pMHC-induced structural changes in the transmembrane and cytoplasmic regions of …