Treacle Ribosome Biogenesis Factor 1 (TCOF1) also known as Treacle is a protein that in humans is encoded by the TCOF1 gene. [5] [6] TCOF1 encodes a nucleolar protein with an …

The TCOF1 gene provides instructions for making a protein called treacle. This protein is active during early embryonic development in structures that become bones and other tissues of the …

Mar 30, 2025 · TCOF1 (Treacle Ribosome Biogenesis Factor 1) is a Protein Coding gene. Diseases associated with TCOF1 include Treacher Collins Syndrome 1 and Crouzon …

Treacher Collins syndrome (TCS) is an autosomal dominant disorder characterized by an abnormality of craniofacial development that arises during early embryogenesis. TCS is …

Data indicate that Treacher Collins-Franceschetti syndrome 1 protein (TCOF1) was the main disease-causing gene for the Chinese Treacher Collins syndrome (TCS) population and its …

HGNC Approved Gene Symbol: TCOF1. By positional cloning, the Treacher Collins Syndrome Collaborative Group (1996) identified a novel gene of unknown function, which they …

The TCOF1 gene product, treacle, responsible for the craniofacial disorder Treacher Collins syndrome, has been predicted to be a member of a class of nucleolar phosphoproteins based …

Oct 20, 2020 · Here, we report that TCOF1 leaves the nucleolus and is recruited to telomeres specifically during S phase by interacting with TRF2. Therein, TCOF1 acts to suppress …

Jan 7, 2024 · TCOF1 coordinates oncogenic activation and rRNA production and promotes tumorigenesis in HCC. TCOF1 upregulation in triple-negative breast cancer promotes …

Mar 1, 2021 · Among all nucleolar proteins, treacle encoded by TCOF1 gene emerges as one of the most crucial regulators of cellular processes. TCOF1 was initially discovered as a gene …