Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. [5][6][7] TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling) expression.

Mar 30, 2025 · TCF3 (Transcription Factor 3) is a Protein Coding gene. Diseases associated with TCF3 include Agammaglobulinemia 8A, Autosomal Dominant and Agammaglobulinemia 8B, Autosomal Recessive. Among its related pathways are …

TCF3 is a transcription factor contributing to early lymphocyte differentiation. Germline monoallelic dominant negative and biallelic loss-of-function (LOF) null TCF3 mutations cause a fully penetrant severe immunodeficiency.

Jan 5, 2025 · Gene target information for TCF3 - transcription factor 3 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

The TCF3 gene, also called E2A, encodes 2 basic helix-loop-helix (bHLH) transcription factors, E12 and E47, through alternative splicing. E12 and E47 are involved in regulation of immunoglobulin gene expression (Bain et al., 1994). TCF3 plays an important role in B-cell development and differentiation (summary by Ben-Ali et al., 2017).

Jun 26, 2021 · Mechanistically, we found that EZH2 promoted EC cell proliferation by epigenetically repressing TCF3, a direct transcriptional activator of CCKN1A (p21WAF1/Cip1), in vitro and in vivo.

In this study, we identified new regulatory targets of Tcf3 using a whole-genome approach and found that Tcf3 transcriptionally represses many genes important for maintaining pluripotency and self-renewal, as well as those involved in lineage commitment and stem cell differentiation.

Jun 9, 2024 · Clinical resource with information about TCF3, A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus., Agammaglobulinemia 8, autosomal dominant, Agammaglobulinemia 8b, autosomal recessive, and available tests.

Dec 31, 2023 · In our study, TCF3 was found to express highly and correlated with cancer stage and prognosis. TCF3 was shown to promote ESCC invasion, migration, and drug resistance both from the results of in vivo and in vitro assays.

Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis. Rare TCF3 variants associated with pediatric B cell acute lymphoblastic leukemia. Transcription Factor TCF3 Promotes Macrophage-Mediated Inflammation and MMP Secretion in Abdominal Aortic Aneurysm by Regulating miR-143-5p /CCL20.