Understanding how Tcf1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies. This review discusses Tcf1, which plays context-dependent roles in T cell function during autoimmunity, cancer, and chronic infection.

Oct 6, 2021 · The transcription factor TCF-1 has multiple roles during T cell development and in mature T cells. Gounari and Khazaie review the potential mechanisms by which TCF-1 regulates gene...

Jun 14, 2021 · In the cytotoxic T cell lineages, TCF1 is required for the self-renewal of stem-like CD8 + T cells generated in response to viral or tumour antigens, and for preserving heightened responses to...

T cell factor-1 (TCF-1) (encoded by the TCF7 gene) is a transcription factor that plays important role during the T cell development and differentiation for T cell to exercise its functions including producing memory T cells.

TCF-1 is important in driving the development of T MP and T CM cells. In both acute and chronic LCMV infection, downregulation of TCF-1 is needed for the differentiation of T EFF and T EX cells.

The T cell-specific DNA-binding protein TCF-1 is a central regulator of T cell development and function along multiple stages and lineages. Because it interacts with β-catenin, TCF-1 has been classically viewed as a downstream effector of canonical Wnt signaling, although there is …

Understanding how TCF1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies. T cell factor 1 (TCF1, encoded by Tcf7) is the key transcription factor of the canonical WNT signaling pathway (Fig. 1A).

TCF-1, encoded by the TCF7 gene, orchestrates gene expression essential for T cell lineage commitment during early development in the thymus. It is vital for transitioning thymocytes from the double-negative (DN) to the double-positive (DP) stage, directly regulating T cell receptor (TCR) gene rearrangement.

Tcf-1 (encoded by Tcf7) not only plays critical roles in promoting T cell development and differentiation but also has been identified as a tumor suppressor involved in preventing T cell malignancy. However, the comprehensive mechanisms of Tcf-1 ...

Our data in TCF-1 expressing fibroblasts led to two observations: (1) TCF-1 can generate chromatin accessibility at previously repressed domains and (2) TCF-1 can induce the expression of thousands of genes.