Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked to the metabolism …

Feb 1, 2025 · SIRT3 can scavenge excess ROS by deacetylating MnSOD2, IDH2, and PHD. In addition, SIRT3 regulates the TCA cycle, oxidative phosphorylation, ETC, fatty acid, and …

Recent studies suggest that sirtuin 3 (SIRT3), the mitochondrial NAD + -dependent deacetylase, may regulate mitochondrial function and biosynthetic pathways such as glucose and fatty acid …

SIRT3 is a NAD+-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is emerging as an …

Mar 16, 2022 · In addition to increased glucose catabolism in activated T cells, glutamine uptake and glutaminolysis are also upregulated to supply the tricarboxylic acid (TCA) cycle for ATP …

Oct 13, 2016 · SIRT3 target enzymes range through almost all substrate oxidation and ATP-generating processes from pyruvate import (mitochondrial pyruvate carrier), TCA cycle activity …

Feb 20, 2022 · SIRT3, the most prominent deacetylase in mitochondria, regulates fatty acid and glucose metabolism, and participates in TCA, ETC, and ATP synthesis, thereby maximizing …

Jun 1, 2023 · SIRT3, a major deacetylase in mitochondria, regulates almost every aspect of mitochondrial health and functionality. SIRT3 controls vital functions like energy balance, …

Mar 30, 2023 · By deacetylating and activating antioxidants, SIRT3 helps regulate ROS levels. Moreover, SIRT3 activates enzymes responsible for the tricarboxylic acid (TCA) cycle and …

Aug 2, 2024 · Sirtuin 3 (SIRT3) is the major protein deacetylase of mitochondria. SIRT3 serves as a nutrient sensor; under conditions of mild metabolic stress, SIRT3 activity is increased. Within …