Here, we cover the importance of timing, location, and quality of CD4 T-cell responses during M. tuberculosis infection, how CD8 T cells contribute to immunity against M. tuberculosis, the roles that inhibitory receptors play during infection, the phenotypes and functions of memory T cells, and the roles that B cells, γδ T cells, CD1 ...

Mtb is a slow growing mycobacteria with a doubling time of 12–24 h under optimal conditions. A major feature of Mtb is the peculiar cell wall structure, that provides an exceptionally strong impermeable barrier to noxious compounds and drugs and that plays a …

Through a brief and complete overview of the role of each cell type involved in the Mtb response, we aimed to highlight the main literature reviews and the most relevant studies in order to facilitate the approach to such a complex and changeable topic.

Dec 8, 2022 · The causative pathogen, Mycobacterium tuberculosis deploys multiple mechanisms to evade host immune responses, thus challenging the development of an effective vaccine. This review highlights the importance of understanding immune cells in tuberculosis in a holistic manner to better achieve protective immunity.

Jul 13, 2012 · Evidence that adaptive (or maladaptive) immune responses in tuberculosis promotes tissue damage and the transmission of M. tuberculosis demands additional study in order to determine whether...

Here, we review recent findings on CD4 (+) and CD8 (+) T-cell responses to M. tuberculosis infection and examine the roles of distinct M. tuberculosis-specific T-cell subsets in control of de novo and latent M. tuberculosis infection, and in the evolution of T-cell immunity to M. tuberculosis in response to tuberculosis treatment.

Mar 30, 2011 · In this review, we have concentrated on recent studies that provide insights into the early cellular and molecular processes underlying the initiation of adaptive immune responses in TB.

Dec 8, 2022 · This review focuses on certain immunological elements that have recently yielded exciting data and highlights the importance of taking a holistic approach to understanding the interaction of M. tuberculosis with the many host cells that contribute to the development of protective immunity.

Mar 8, 2023 · They find peptide antigen-specific T cells correlating with control of primary infection, potentially informing future vaccines.

This review comprises a comprehensive literature on conventional and unconventional T cells, highlighting the polyfunctional T cells as well, their role in controlling TB infection, and their implications in the spectrum of TB infection.