Taste receptor 2 member 38 is a protein that in humans is encoded by the TAS2R38 gene. TAS2R38 is a bitter taste receptor; varying genotypes of TAS2R38 influence the ability to taste both 6-n-propylthiouracil (PROP) [5] and phenylthiocarbamide (PTC).

Here we studied the distribution of TAS2R38 haplotypes in a large number of human populations and available archaic hominid genomes to provide a fine-scale view of worldwide TAS2R38 diversity, and we applied selection tests to evaluate the processes underlying the evolution of TAS2R38 haplotypes.

Dec 2, 2019 · Here we evaluated the role of the bitter receptor TAS2R38 in attainment of longevity, since it has been widely associated with individual differences in taste perception, food preferences, diet,...

The human TAS2R38 gene encodes a bitter taste receptor that regulates the bitterness perception and differentiation of ingested nutritional/poisonous compounds in the oral cavity and gastrointestinal tract.

Apr 7, 2025 · Title: Association of the bitter taste genes TAS2R38 and CA6 and breast cancer risk; a case-control study of Polish women in Poland and Polish immigrants in USA. Genetic variation in TAS2R38 bitterness receptor is associated with body composition in Korean females.

TAS2R38 encodes a taste receptor that confers bitter taste sensing from chemicals found in some vegetables. Common polymorphisms in TAS2R38 lead to coding substitutions that alter receptor function and result in the loss of bitter taste perception.

Our findings show that a simple PTC filter paper tasting method strongly predicts TAS2R38 genotype, and that the genotype-phenotype association is similar among ethnocultural groups.

May 5, 2022 · Bitter taste receptor TAS2R38 is expressed in the respiratory tract and can respond to quorum-sensing molecules produced by pathogens, stimulating the release of nitric oxide, with biocidal...

Mar 30, 2025 · TAS2R38 (Taste 2 Receptor Member 38) is a Protein Coding gene. Diseases associated with TAS2R38 include Thiourea Tasting and Dental Caries. Among its related pathways are GPCR downstream signalling and Sensory perception of taste.

Nov 2, 2024 · Genotype-specific regulation of oral innate immunity by T2R38 taste receptor. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. Genetics of the taste receptor T2R38 correlates with …