TAL1 (SCL/TAL1, T-cell acute leukemia protein 1) is a transcription factor that is involved in the process of hematopoiesis and leukemogenesis. It participates in blood cell formation, forms mesoderm in early embryogenesis, and regulates hematopoiesis in adult organisms.

5 days ago · Polyclonal Antibody for studying TAL1. Validated for WB. Highly specific and rigorously validated in-house, TAL1 Antibody (CST #12831) is ready to ship.

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy derived from thymic T-cell precursors. Approximately 40-60% of T-ALL cases exhibit aberrant overexpression of the TAL1 oncogenic transcription factor. Here, we provide a ...

Nov 11, 2012 · Here we reported that PKA mediated phosphorylation regulates TAL1 interaction with the lysine specific demethylase (LSD1) that removes methyl group from methylated Lys 4 on histone H3 tails.

Feb 2, 2011 · TAL1/SCL is a master regulator of haematopoiesis whose expression promotes opposite outcomes depending on the cell type: differentiation in the erythroid lineage or oncogenesis in the T-cell lineage. Here, we used a combination of ChIP sequencing and gene expression profiling to compare the function of TAL1 in normal erythroid and leukaemic T ...

May 1, 2023 · We identified a putative novel oncogenic neo-enhancer downstream of TAL1 in an unresolved monoallelic TAL1+ case. A rare but recurrent somatic heterozygous microinsertion within this region creates a de novo binding site for MYB transcription factor.

Jun 6, 2009 · We found that TAL1 recruits LSD1 complexes and HDM activity to a TAL1 target promoter. It represses transcription of the target gene by altering the histone H3K4 methylation pattern on the promoter, which suggests that TAL1 might regulate transcription by manipulating the histone code.

Mar 1, 1998 · Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. Ono Y et al 7568177

TAL1, also known as SCL, is a transcription factor that plays a crucial role in early hematopoiesis. It is expressed in normal erythroid precursors and megakaryocytes, but not in normal T cells.

Dec 19, 2013 · GATA1-dependent chromatin looping at the TAL1 locus accounts for many biological and evolutionary features of TAL1 expression. Chromatin looping also regulates expression of TAL1 flanking genes and brings TAL1 and STIL into close proximity at …