- The tyrosine kinase Syk plays a crucial role in inflammatory signaling pathways and has gained much attention as a potential target for treatment of inflammatory disorders.Author: Zhen-Yu Huang, Moo-Kyung Kim, Tae-Hee Kim-Han, Zena K. Indik, Alan D. SchreiberPublish Year: 2013www.sciencedirect.com/science/article/pii/S0161589012003331
Tyrosine Kinase SYK is a Potential Therapeutic Target for Liver ...
Spleen tyrosine kinase (SYK) plays a critical role in immune cell signaling pathways and has been reported as a novel biomarker for human hepatocellular carcinoma (HCC). We sought to …
- Author: Chen Qu, Dandan Zheng, Sai Li, Yingjun Liu, Anna Lidofsky, Jacinta A. Holmes, Jianning Chen, Lu He, ...
- DOI: 10.1002/hep.29881
- Publish Year: 2018
- Published: 2018/09
See results only from ncbi.nlm.nih.govFigure - PMC - National Cent…
Spleen tyrosine kinase (SYK) plays a critical role in immune cell signaling pathways …
Calling in SYK: SYK’s dual rol…
Most are dependent on SYK expression and activity for survival as both siRNAs …
Getting Syk: Spleen Tyrosine …
The direct injection of naked Syk siRNA into joints ameliorates swelling and …
Effect of locally administere…
We have shown that our Syk siRNA injected directly into limb joints of arthritic mice, …
Targeting SYK of monocyte-derived macrophages regulates liver …
Dec 1, 2021 · Our studies based on chronic CCL4, bile duct ligation, and subacute TAA mouse models show that SYK in monocyte-derived macrophages (MoMFs) is fully dependent on …
- Author: Xuejiao Chen, Xuejiao Chen, Ziyi Wang, Ziyi Wang, Sheng Han, Sheng Han, Zeng Wang, Zeng Wang, Yu Zha...
- Publish Year: 2021
SYK-mediated epithelial cell state is associated with …
May 15, 2023 · Spleen tyrosine kinase (SYK) is a cytoplasmic kinase that couples immune cell receptors to induce intracellular signaling pathways and plays a central role in adaptive and inflammatory immune...
- Studies of Syk siRNA
Calling in SYK: SYK’s dual role as a tumor promoter and …
Most are dependent on SYK expression and activity for survival as both siRNAs directed against SYK mRNA and the SYK inhibitor R406 induce apoptosis in these cells. In acute myeloid leukemia (AML), integrins can function upstream …
Getting Syk: Spleen Tyrosine Kinase as a Therapeutic Target
The direct injection of naked Syk siRNA into joints ameliorates swelling and inflammation in a mouse model of arthritis , supporting a direct role for Syk inhibition in alleviating RA pathology.
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Effect of locally administered Syk siRNA on allergen-induced
We have shown that our Syk siRNA injected directly into limb joints of arthritic mice, diminishes joint swelling and reduces levels of Syk kinase and inflammatory cytokines in joint tissue.
Inhibition of Syk protein tyrosine kinase induces …
Sep 24, 2009 · To determine whether Syk contributes to the growth and survival of T-cell lymphomas, a small interfering RNA (siRNA) approach was used to inhibit Syk expression. Syk siRNA effectively silenced...
Effect of locally administered Syk siRNA on allergen-induced …
Jan 1, 2013 · We have shown that our Syk siRNA injected directly into limb joints of arthritic mice, diminishes joint swelling and reduces levels of Syk kinase and inflammatory cytokines in joint …
New insights into SYK targeting in solid tumors - Cell …
Sep 24, 2024 · Spleen tyrosine kinase (SYK), a non-receptor tyrosine kinase that is overexpressed in several solid tumors, presents a promising therapeutic target. SYK activation downstream of various receptors drives signaling pathways …
Antibody-mediated platelet phagocytosis by human macrophages …
Immune thrombocytopenia depends upon Fc receptor-mediated phagocytosis that involves signaling through the SH2 tyrosine kinase, Syk. We designed small interfering (siRNA) …