The Syk-NFAT-IL-2 Pathway in Dendritic Cells Is Required for …
Jan 1, 2017 · Using chimeric mice, we show that DC-derived IL-2 is required for maximal Ag-specific proliferation of CD4 + T cells and optimal humoral responses following alum …
The SYK tyrosine kinase: a crucial player in diverse biological ...
Moreover, SYK couples PAMP recognition to de novo gene transcription and induces chemokine and cytokine production through several downstream pathways including the ERK signalling …
Two Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk ...
Activated Syk, an essential tyrosine kinase in B cell signaling, interacts with Vav guanine nucleotide exchange factors and regulates Vav activity through tyrosine phosphorylation. The …
Functional Roles of Syk in Macrophage-Mediated Inflammatory …
Spleen tyrosine kinase (Syk) is a nonreceptor tyrosine kinase with a molecular weight of 72 kDa. Syk binds with TLR4 and is activated by phosphorylation mainly at tyrosine residues, resulting …
NFAT control of innate immunity | Blood - American Society of …
Aug 16, 2012 · Microbial ligation of pattern-recognition receptors, such as TLR4, CD14, and dectin 1, is now known to induce the activation of calcineurin/NFAT signaling in myeloid cells, …
SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies
In the sole presence of SYK, pathological BCR-signaling in autoreactive or premalignant cells induces NFAT-activation and NFAT-dependent anergy and negative selection.
NFAT signaling in human mesenchymal stromal cells affects …
Jun 25, 2021 · We report that MSCs phagocytose the fungal component zymosan, resulting in phosphorylation of spleen tyrosine kinase (Syk), increase in cytosolic calcium levels, and …
Developmental partitioning of SYK and ZAP70 prevents …
Apr 19, 2021 · Coexpression of ZAP70 with SYK dramatically reduced BCR-induced NFAT nuclear localization (Figures 3E and 3F), whereas total NFAT levels were not altered (Figure …
The Syk–NFAT–IL-2 Pathway in Dendritic Cells Is Required for …
Jan 1, 2017 · Taken together, our findings identify the Syk/Src–Ca 2+ –NFAT pathway as the master regulator of IL-2 production in DCs upon exposure to sterile particulates. DC-derived IL …
The SYK tyrosine kinase: a crucial player in diverse biological ...
May 14, 2010 · Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, …