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    https://www.sciencedirect.com › science › article › pii

    Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate …

    • ••
      MyD88 is posttranscriptionally regulated by tyrosine phosphorylation
      ••… See more

    Summary

    Mice carrying a hypomorphic point mutation in the Ptpn6 gene (Ptpn6spin mice) … See more

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    Keywords

    SHP1
    Ptpn6
    SYK
    IL-1α
    IL-1β… See more

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    Introduction

    Mutations in the PTPN6 gene that encodes for the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1 (SHP1) have been linked with autoinf… See more

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    Results

    Ptpn6spin Mutation in the Non-Hematopoietic Compartment Is Dispensable for Inflammatory Disease
    IL-1 receptor signaling and MyD88 are centrally re… See more

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    Discussion

    Polymorphisms in the human PTPN6 gene are associated with a wide spectrum of autoinflammatory diseases (Cao and Hegele, 2002, Christophi et al., 2008). Therefore, … See more

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    Experimental Procedures

    Mice
    Genetic mutant mice were previously described or were purchased from the Jackson Laboratory (please see Supplemen… See more

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