Inhibition of cyclin-dependent kinase 5 affects early …
Jan 4, 2018 · Roscovitine (intraperitoneal administration) was used as a potent Cdk5 inhibitor. The experiments were also performed on human neuroblastoma SH-SY5Y as well as mouse …
- Author: Anna Wilkaniec, Magdalena GÄ…ssowska-Dobrowolska, Marcin Strawski, Agata Adamczyk, Grzegorz A. Czapsk...
- DOI: 10.1186/s12974-017-1027-y
- Publish Year: 2018
- Publication: J Neuroinflammation. 2018; 15: 1.
Stress-induced nuclear translocation of CDK5 …
Jun 27, 2016 · Here we report that oxidative stress-induced cyclin-dependent kinase 5 (CDK5) activation stimulates neuroprotective signaling via …
- Author: Haengjin Song, Wanil Kim, Jung-Hyun Choi, Sung-Hoon Kim, Dohyun Lee, Choon-Ho Park, Sangjune Kim, Do...
- Publish Year: 2016
Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an ...
SH-SY5Y cells were treated with OA (100 nM) in the presence of absence of 17β-estradiol (E2, 10 μM) and ICI 182,780 (1 μM) for three hours. cdk5 (A) and p25 (B) were assessed via …
- Studies of Sy5y Cdk5
The retinoic acid and brain-derived neurotrophic factor ... - PubMed
Jul 2, 2004 · We also investigated whether GSK3beta, Cdk5 or JNK was involved in tau phosphorylation in the differentiated SH-SY5Y cells. We found that GSK3beta contributed …
- Author: Anne Jämsä, Kristina Hasslund, Richard F Cowburn, Anders Bäckström, Mervi Vasänge
- Publish Year: 2004
Glutamate treatment and p25 transfection increase Cdk5 …
Jun 23, 2006 · Our results with the SH-SY5Y cells show that glutamate increases tau phosphorylation, which we suggest to be caused by an increase in Cdk5 activity, which in turn …
- Author: Anne Jämsä, Anders Bäckström, Elin Gustafsson, Nodi Dehvari, Gösta Hiller, Richard F. Cowburn, Richa...
- Publish Year: 2006
Stabilization and activation of p53 induced by Cdk5 contributes to ...
Jul 1, 2007 · Nuclear preparations from mitomycin C-treated SH-SY5Y cells showed increased expression of Cdk5 and its activator p35, as well as enhanced Cdk5 activity . Similarly, under …
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The Cdk5/p35 kinases modulate leptin-induced STAT3 signaling
The Cdk5 inhibitor roscovitine modulates leptin-induced pSTAT3 in SH-SY5Y cells. Leptin (30 nM) increased pSTAT3 (both Y 705 and S 727) between 30 min – 6 h of treatment; the increase at …
An okadaic acid-induced model of tauopathy and cognitive …
Phosphorylated tau as well as cyclin-dependent kinase 5 (cdk5) and its coactivator, p25, were significantly increased in these regions of the brain. Oxidative stress was also increased with …
Role of CDK5 in neuroprotection from serum deprivation by μ …
Dec 1, 2006 · To understand how CDK5 participates in such disparate cellular outcomes, we investigated whether activation of CDK5 could mediate neuroprotection from serum …
Cyclin-dependent kinase-5 prevents neuronal …
Nov 4, 2005 · Here, we show that Cdk5 kinase activity prevents neuronal apoptosis through the upregulation of Bcl-2. Treatment of SH-SY5Y cells with retinoid acid (RA) and brain-derived neurotrophic factor...
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