‘Super p53’ mice, carrying p53-tg alleles in addition to the two endogenous alleles, exhibit an enhanced response to DNA damage. Importantly, ‘super p53’ mice are significantly protected …

The super p53 mice carry extra copies of a complete p53 gene, including the p53 promoter and upstream regulatory region . As expected, these mice display augmented p53 activity in …

Nov 21, 2002 · One of the most intensively studied of cellular molecules, the p53 protein is well known for its role as a tumour suppressor: it helps to protect against cancer by regulating the …

Nov 15, 2002 · These “super p53” mice not only showed enhanced activation of the p53-dependent response to DNA damage, but they developed significantly fewer tumors after …

More than half of human cancers contain mutations in the tumor suppressor protein p53, most of which accumulate in the DNA binding domain of the protein. Here we report the identification …

Garcia-Cao and collaborators report the generation of novel transgenic mice, called “super p53.” The super p53 mice express wild-type endogenous p53, and also carry one or two extra …

Jun 7, 2013 · Garcia-Cao et al. (2002) generated “super p53” mice carrying supernumerary fully functional copies of the p53 gene in the form of large genomic transgenes. These super p53 …

Jul 7, 2016 · Super p53 mice had significantly reduced survival compared to WT p53 mice (Figure 1B), demonstrating that an extra copy of p53 sensitizes mice to the hematopoietic acute …

'Super p53' mice, carrying p53‐tg alleles in addition to the two endogenous alleles, exhibit an enhanced response to DNA damage. Importantly, 'super p53' mice are significantly protected …

In line with phenotypes of p53 +/m and P+/+ mice, Garcia-Cao et al. showed that transgenic mice carrying one or two extra copies of wild-type p53 genes (super-p53 or p53 tg mice) were …