Syntaxin-2, also known as epimorphin, is a protein that in humans is encoded by the STX2 gene. [5] [6] [7] The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and …

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Stx is found in Shigella dysenteriae 1 and in some serogroups of Escherichia coli (called Stx1 in E. coli). In addition to or instead of Stx1, some E. coli strains produce a second type of Stx, Stx2, that has the same mode of action as Stx/Stx1 but that is antigenically distinct.

Mar 30, 2025 · STX2 (Syntaxin 2) is a Protein Coding gene. Diseases associated with STX2 include Acute Diarrhea and Dysentery. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Sertoli-Sertoli Cell Junction Dynamics.

Stx2 is a potent toxin produced by certain harmful E. coli bacteria, causing health issues like stomach cramps, diarrhea, and potentially kidney damage if ingested through contaminated food or water.

Shiga toxin (Stx)-producing Escherichia coli (STEC) strain B2F1 produces Stx type 2d, a toxin that becomes more toxic towards Vero cells in the presence of intestinal mucus. STEC that make Stx2d are more pathogenic to streptomycin (Str)-treated …

STX2 drives colorectal cancer proliferation via upregulation of EXOSC4. STX2 as a crucial modulator of the aggressive colorectal cancer phenotype. he patient showed azoospermia, relatively small testes, and a mildly elevated follicle stimulating hormone level, but no additional clinical features.

Shiga toxin-producing Escherichia coli (STEC) strains are human pathogens linked to hemorrhagic colitis and hemolytic uremic syndrome. Shiga toxins (Stx1 and Stx2) are the major virulence factors of these strains.

Variants of Stx2 include Stx2c, Stx2d, Stx2d-activable, Stx2e, and Stx2f. Only the Stx2c variant of Stx2 has been found in the O157 serotypes. The Stx2 variants are distinguished by a difference in biological activity, immunological reactivity, or the receptor to which they bind.

Background: Shiga-like toxin 2 (Stx2) is one of the most important virulence factors in enterohaemorrhagic Escherichia coli (E. coli) strains such as O157H7. Subtypes of Stx2 are diverse with respect to their sequence, toxicity, and distribution.