In this study, we developed a DPZ ionic liquid (IL) transdermal patch—a novel transdermal preparation of DPZ that can overcome the current drawbacks. DPZ is an acetylcholinesterase inhibitor used to treat cognitive symptoms in mild to moderate AD [3,4,5]. In particular, it appears to benefit both cognitive ability and mental function [4,5 ...

There is strong evidence that donepezil has efficacy against the three major domains of Alzheimer’s disease symptoms, namely functional ability, behavior, and cognition. The strongest evidence is for improvement or less deterioration in global outcomes and cognition in …

In this case, the use of some acetylcholinesterase (AChE) inhibitors including galantamine, risvastigmine, and donepezil hydrochloride (DPZ) have been used to improve cholinergic function. DPZ is a second-generation drug used for the treatment of neurodegenerative disease that works via the impairment of cholinergic neurotransmission [6,7].

Aug 13, 2024 · The current study endeavors to design an in situ gel for intranasal delivery of a DPZ nanostructured lipid carrier (DPZ-NLC) to boost pharmacokinetic and pharmacodynamic outcomes. The Box–Behnken design was employed to optimize the NLCs that were produced utilizing a melt emulsification high-pressure homogenization process.

Sep 1, 2022 · Chitosan coated Donepezil-loaded nanostructured lipid carrier (DPZ-CH-NLC) was proposed for the nose to brain delivery. •NLCs were prepared by homogenization and sonication technique and optimized by three factors-three levels Box-Behnken design.

Nov 5, 2022 · Results showed that pluronic gels exhibit the higher release rate and enhanced permeation compared to chitosan gel. Moreover, the combination of Pluronic F-127 and Transcutol ® P exerted a synergic effect on the permeation of …

Oct 14, 2024 · Pharmacokinetic study and behavioral test were performed to determine the brain exposure and therapeutic effects after ICO of DPZ@LAM in scopolamine-induced memory-deficient mice. Results: DPZ@LAM were capable of a …

Feb 9, 2023 · The present study demonstrates the feasibility of the in situ precipitation technique for the development of DPZ microparticulate formulations. LAI formulations were successfully developed for 1-week DPZ delivery.

Nov 5, 2022 · Results showed that pluronic gels exhibit the higher release rate and enhanced permeation compared to chitosan gel. Moreover, the combination of Pluronic F-127 and Transcutol® P exerted a synergic...

Jun 15, 2024 · DPZ in combination with BP is highly effective for the treatment of PSCI. It positively affects cognitive function and ADL, alleviates neurological deficits, and reduces abnormal serum biochemical indices without increasing the risk of adverse reaction.