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Studies of Strn3 PP2
National Center for Biotechnology Information
STRN3 promotes tumour growth in hepatocellular carcinoma by inhibiting the hippo pathway
HCC is a globally high‐incidence malignant tumour, and its pathogenesis is still unclear. Recently, STRN3 has been found to be elevated in various tumours, but its expression and biological functions in HCC have not been studied. In the study, clinical correlation analysis was performed on 371 liver...
Author: Jie Zhu, Wenji…
Published: 2024/03
Publication: J Cell Mo…
National Center for Biotechnology Information
Reactivating Hippo by drug compounds to suppress gastric cancer and enhance chemotherapy sensitivity
The Hippo signaling pathway plays an essential role in organ size control and tumorigenesis. Loss of Hippo signal and hyper-activation of the downstream oncogenic YAP signaling are commonly observed in various types of cancers. We previously identified STRN3-containing PP2A phosphatase as a negative...
Author: Zhifa Cao, Yu …
Published: 2024/06
Publication: J Biol Che…
PubMed
Good Guy in Bad Company: How STRNs Convert PP2A into an Oncoprotein
Certain Protein Phosphatase 2A (PP2A) complexes are human tumor suppressors. In contrast, a paper in this issue of Cancer Cell and two other recent studies demonstrate that PP2A-STRN3/4 complexes inactivate Hippo tumor suppressor pathway, resulting in YAP activation and tumorigenesis. Furthermore, t...
Author: Kari J Kurppa
Published: 2020/07/13
Keywords: National In…
National Center for Biotechnology Information
Cellular Impacts of Striatins and the STRIPAK Complex and Their Roles in the Development and Metastasis in Clinical Cancers (Review)
Simple Summary The STRIPAK (striatin-interacting phosphatase and kinase) complex and its central components, striatins (STRNs), have attracted significant interest with regard to the pathological development of diseases over the last decade, particular in the area of cancer research. Beyond their r...
Author: Amber Xinyu L…
Published: 2024/01
Publication: Cancers (…
PubMed
https://pubmed.ncbi.nlm.nih.gov
Selective Inhibition of STRN3-Containing PP2A Phosphatase
Jul 13, 2020 · We identified STRN3 as an essential regulatory subunit of protein phosphatase 2A (PP2A) that recruits MST1/2 and promotes its dephosphorylation, which results in YAP …
- Author: Yang Tang, Yang Tang, Gemin Fang, Fenghua Guo, Hui Zhang, Xiaoxu Chen, Liwei An, Min Chen, Li Zhou, ...
- Publish Year: 2020
Cell Press
https://www.cell.com › cancer-cell › fulltext
Good Guy in Bad Company: How STRNs Convert PP2A …
Jul 13, 2020 · Disrupting this interface by mutating PP2A-A or STRN3 decreased YAP activity and impaired proliferation and colony formation of gastric cancer …
Author: Kari J. Kurppa, Jukka Westermarck, Jukka Westermarck
Publish Year: 2020
Cell Press
https://www.cell.com › cancer-cell › fulltext
Selective Inhibition of STRN3-Containing PP2A …
We identified STRN3 as an essential regulatory subunit of protein phosphatase 2A (PP2A) that recruits MST1/2 and promotes its dephosphorylation, which …
Author: Yang Tang, Yang Tang, Gemin Fang, Fenghua Guo, Hui Zhang, Xiaoxu Chen, Liwei An, Min Chen, Li Zhou, ...
Publish Year: 2020
Nature
https://www.nature.com › articles
Cryo-EM structure of the Hippo signaling integrator …
Feb 25, 2021 · Using cryo-EM, we determine the structure of the human STRIPAK core comprising PP2AA, PP2AC, STRN3, STRIP1, and MOB4 at …
Author: Byung Cheon Jeong, Sung Jun Bae, Lisheng Ni, Xuewu Zhang, Xiao chen Bai, Xuelian Luo
Publish Year: 2021
Cell Press
https://www.cell.com › cancer-cell › pdf
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Selective Inhibition of STRN3-Containing PP2A - Cell Press
We identified STRN3 as an essential regulatory subunit of protein phospha-tase 2A (PP2A) that recruits MST1/2 and promotes its dephosphorylation, which results in YAP activation. We also …
- File Size: 5MB
- Page Count: 24
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
STRN3 promotes tumour growth in hepatocellular carcinoma by …
Mar 1, 2024 · Previous research has shown that STRN3 acts as a regulatory subunit of PP2A, influencing the activation of the YAP‐Hippo axis. 8, 14 However, it remains unknown whether …
People also ask
Does STRN3 phosphorylate PP2A phosphatase?
We show that STRN3 recruits MST1/2 to the PP2A core enzyme complex, resulting in MST1/2 dephosphorylation and loss of Hippo signaling. Exploiting the unique mode of interaction between STRN3 and PP2A, we developed the peptide SHAP to selectively target STRN3-containing PP2A phosphatase.
Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores
cell.com
Does STRN3 interact with PP2A?
To structurally characterize the STRN3-PP2A interaction, we first used gel filtration to confirm the formation of a stable complex between PP2Aa and a fragment of the coiled-coil domain (amino acid residues 86–131) of STRN3 (Figure S3 E).
Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores
cell.com
Does STRN3 coiled-coil interact with PP2A?
Consistent with our previous studies 35, the coiled-coil domain (CC, amino acid residues 64–145) of STRN3 was shown using maltose-binding protein (MBP) pulldown assay to directly interact with the regulatory A subunit of PP2A (PP2Aa) but not with its catalytic C subunit (PP2Ac) (Fig. 1d).
Architecture, substructures, and dynamic assembly of STRIPAK complex…
nature.com
Does STRN3 cc interact with MST2 protein?
In contrast, STRN3 CC but not STRN3 Core protein was indicated to directly interact with MST2 protein (Figure S5 D). These results suggested that shortening of the coiled-coil region of STRN3 would abolish its function to recruit MST1/2 to the PP2A core enzyme.
Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores
sciencedirect.com
Does STRN3 core compete with PP2Aa?
Considering the unique property of STRN3 Core described above, we reasoned that it may potentially compete with endogenous full-length STRN3 for PP2Aa binding, thus abrogating STRN3-PP2A-mediated inactivation of MST1/2 kinases (Figure 4 D).
Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores
sciencedirect.com
Where is the structural coordinate of STRN3 PP2Aa complex deposited?
The structural coordinate of STRN3–PP2Aa complex was deposited in the PDB database under the code PDB: 6IUR. The GEO accession numbers for the high-throughput sequencing reported in this paper are GSE135085 and GSE135086.
Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores
cell.com
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biologists.com
https://journals.biologists.com › jcs › article › Protein...
Protein phosphatase 2A – structure, function and role in ...
Jul 6, 2021 · The structure of PP2A-B‴ (STRN3) has an N-terminal coiled-coil domain, a central CCM3- binding domain and a C-terminal WD40 domain (PDB ID: 7K36; Jeong et al., 2021). …
ScienceDirect
https://www.sciencedirect.com › science › article › pii
Selective Inhibition of STRN3-Containing PP2A ... - ScienceDirect
Jul 13, 2020 · We identified STRN3 as an essential regulatory subunit of protein phosphatase 2A (PP2A) that recruits MST1/2 and promotes its dephosphorylation, which results in YAP …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
Reactivating Hippo by drug compounds to suppress gastric cancer …
Apr 22, 2024 · Here, we revisited the STRN3-containing PP2A and STRIPAK complex and discovered that pharmacological targeting of the PP2Aa–STRN3 or STRN3–MST1/2 …
Nature
https://www.nature.com › articles
Architecture, substructures, and dynamic assembly of STRIPAK …
Jan 8, 2019 · PP2Aa/c-bound STRN3 directly contacts the Hippo kinase MST2 and also controls the loading of MST2 via two “arms” in a phosphorylation-dependent manner, one arm being …
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Selective Inhibition of STRN3-Containing PP2A Phosphatase

Good Guy in Bad Company: How STRNs Convert PP2A …

Selective Inhibition of STRN3-Containing PP2A …

Cryo-EM structure of the Hippo signaling integrator …

Selective Inhibition of STRN3-Containing PP2A - Cell Press

STRN3 promotes tumour growth in hepatocellular carcinoma by …

Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores

Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores

Architecture, substructures, and dynamic assembly of STRIPAK complex…

Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores

Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores

Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores

Protein phosphatase 2A – structure, function and role in ...

Selective Inhibition of STRN3-Containing PP2A ... - ScienceDirect

Reactivating Hippo by drug compounds to suppress gastric cancer …

Architecture, substructures, and dynamic assembly of STRIPAK …