Fate by RNA methylation: m6A steers stem cell pluripotency
Feb 22, 2015 · The N 6-methyladenosine (m6A) modification of mRNA has a crucial function in regulating pluripotency in murine stem cells: it facilitates resolution of naïve pluripotency …
The role of m6A modification in the biological functions and
Feb 21, 2021 · N 6 -methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic …
m6A modulates haematopoietic stem and progenitor cell ... - Nature
Sep 6, 2017 · Here we show that m 6 A determines cell fate during the endothelial-to-haematopoietic transition (EHT) to specify the earliest haematopoietic stem/progenitor cells …
m6A modulates haematopoietic stem and progenitor cell ... - PubMed
Sep 14, 2017 · Here we show that m 6 A determines cell fate during the endothelial-to-haematopoietic transition (EHT) to specify the earliest haematopoietic stem/progenitor cells …
m6A RNA Modification Controls Cell Fate Transition in …
Dec 4, 2014 · N6-methyl-adenosine (m6A) is the most abundant modification on messenger RNAs. Batista et al. show that core pluripotency factors are regulated by m6A and that …
m(6)A RNA modification controls cell fate transition in mammalian ...
Dec 4, 2014 · N6-methyl-adenosine (m(6)A) is the most abundant modification on messenger RNAs and is linked to human diseases, but its functions in mammalian development are poorly …
m6A RNA Methylation Maintains Hematopoietic Stem Cell …
Aug 13, 2019 · Stem cells balance cellular fates through asymmetric and symmetric divisions in order to self-renew or to generate downstream progenitors. Symmetric commitment divisions …
m6A RNA Methylation Maintains Hematopoietic Stem Cell …
Aug 13, 2019 · As the control of symmetric commitment in adult stem cells is critical for rapidly replenishing tissue compartments after stress or damage, our study highlights the role of RNA …
SON is an essential m6A target for hematopoietic stem cell fate
Dec 7, 2023 · Kharas and colleagues report SON, a central component of nuclear speckles as a critical m6A target required for murine HSC self-renewal, symmetric commitment, and …
Epitranscriptomic m6A modification in the stem cell field and its ...
Our review provides an overview of the m6A epitranscriptomic field and the updated mechanisms of m6A decoration in stem cell regulation. Furthermore, we focus on the role of m6A in DNA …