STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated Janus kinases (JAK), forms homo- or heterodimers, and translocates to the cell nucleus where it acts as a transcription activator.

The first two STAT proteins were identified in the interferon system. There are seven mammalian STAT family members that have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6.

Through its regulation of gene activity, the STAT3 protein is involved in many cellular functions. It helps control cell growth and division (proliferation), cell movement (migration), and the self-destruction of cells (apoptosis). The STAT3 protein is active in tissues throughout the body.

Mar 30, 2025 · STAT3 (Signal Transducer And Activator Of Transcription 3) is a Protein Coding gene. Diseases associated with STAT3 include Hyper-Ige Syndrome 1, Autosomal Dominant, With Recurrent Infections and Autoimmune Disease, Multisystem, Infantile-Onset, 1.

STAT3 is a transcription fac-tor, a type of protein that regulates when other genes are turned on. Once activated, STAT3 moves into the nucleus of the cell and binds to specific areas of DNA. By binding to regula-tory DNA regions near genes, STAT3 controls the activity of a variety of genes.

Dec 3, 2015 · STAT3 is both a transcription activator and an oncogene that is tightly regulated under normal physiological conditions. However, abundant evidence indicates that STAT3 is persistently...

PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]

Signal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, can be phosphorylated by receptor-associated Janus kinases (JAKs) in response to stimulation by cytokines and growth factors. It forms homo- or heterodimers that can translocate to the cell nucleus where they act as transcription activators.

STAT3 functions as a central regulator where multiple signaling pathways are activated by various molecules, including specific cytokines, peptide ligands, growth factors, and oncogenes [5, 6]. These proteins undergo activation through tyrosine phosphorylation in response to cytokine signals within the cytoplasm.

STAT3 is an 89-kDa (770 amino acids) latent cytoplasmic transcription factor characterized by containing each of the following structural protein domains; N-terminal, coiled-coil, DNA binding, linker, SH2 and transcriptional-activation (Fig. 1) [7,20,21].