Structure of the SARS-CoV-2 spike receptor-binding domain …
Mar 30, 2020 · Here, to better understand the initial step of infection at an atomic level, we determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of …
Understanding the role of ACE-2 receptor in pathogenesis of …
The isolated viral spike protein of SARS-CoV-2 was notably reported by few authors in their studies as being responsible to induce downregulation of ACE2 and the over-activity of …
Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 …
Sep 11, 2020 · The novel coronavirus SARS-CoV-2 entry into host cells is mediated by its spike glycoprotein (S-glycoprotein), and the angiotensin-converting enzyme 2 (ACE2) has been …
Structures of the Omicron spike trimer with ACE2 and an anti …
Mar 4, 2022 · We report the structures of the Omicron spike trimer on its own and in complex with angiotensin-converting enzyme 2 (ACE2) or an anti-Omicron antibody. Most Omicron …
COVID-19: angiotensin-converting enzyme 2 (ACE2) expression …
The spike binds to human ACE2 (hACE2) in the cell membrane through the S1 subunit of the receptor-binding domain (RBD). Wrapp et al. [4] documented that SARS-CoV-2 RBD has ~ 10 …
Article Early fusion intermediate of ACE2-using coronavirus spike ...
Mar 6, 2025 · Here, we captured an angiotensin-converting enzyme 2 (ACE2)-induced early fusion intermediate conformation (E-FIC) of severe acute respiratory syndrome coronavirus 2 …
SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 …
Aug 28, 2023 · Mechanisms underling inflammatory processes are unclear, but angiotensin converting enzyme 2 (ACE2), the receptor which binds the spike protein of SARS-CoV-2 may …
Spike-mediated ACE2 down-regulation was involved in the …
Here, we show that SARS-CoV-2 Spike protein downregulates ACE2 expression, thus causing cardiovascular stress by failure to cleave Ang II and subsequently leading to lung injury and …
Structure and inhibition of SARS-CoV-2 spike refolding in
Aug 15, 2024 · The SARS-CoV-2 spike glycoprotein mediates entry into host cells by recognition of the cellular receptor angiotensin converting enzyme 2 (ACE2). Spike is a trimer of …
Engineering human ACE2 to optimize binding to the spike ... - Science
Aug 4, 2020 · The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds angiotensin-converting enzyme 2 (ACE2) on host cells to initiate entry, and …