Spermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells. The precursor for synthesis of spermine is the amino acid ornithine. It is an essential growth factor in some bacteria as well. It is found as a polycation at physiological pH.

Spermine is a spermidine -derived biogenic polyamine found as a polycation at all pH values. Found in various tissues and organisms, it often acts as an essential growth factor in some bacterial species. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.

Numerous studies have reported the level of spermine in different body fluids and organ tissues in patients with different types of cancers. Currently, the role and the underlying mechanisms of spermine in cancer development and progression are still under investigation.

This review describes these alterations and focuses on the roles of spermine which may contribute to these phenotypes including reducing damage due to reactive oxygen species, protection from stress, permitting correct current flow through inwardly rectifying K(+) channels, controlling activity of brain glutamate receptors involved in learning ...

Putrescine, spermine, and spermidine are the important polyamines (PAs), found in all living organisms. PAs are formed by the decarboxylation of amino acids, and they facilitate cell growth and development via different cellular responses.

Aug 19, 2023 · Spermine is a polyamine compound found in the human male reproductive system. It plays a crucial role in sperm function, including sperm maturation and motility. Spermine helps stabilize DNA structure, reduce oxidative damage, and maintain the …

Spermine is a polyamine, which functions as a free radical scavenger. It modulates gene expression, chromatin stabilization and prevents DNA damage. Spermine inhibits endonuclease-mediated DNA fragmentation.

Jan 6, 2014 · Spermine is the most strongly basic polyamine and the great majority of the cellular spermine is bound to acidic sites on macromolecules. Release of spermine from these sites is likely to induce the polyamine back-conversion/catabolic pathways …

Spermine, so named as a polyamine that was first discovered in semen, is present in seminal plasma at concentrations of 50–350 mg/dL and imparts a unique odor to semen. The prostate gland has the highest concentration of spermine in the human body and is the primary source of this polyamine in seminal plasma.

Jun 13, 2005 · Spermine is a spermidine-derived biogenic polyamine found as a polycation at all pH values. Found in various tissues and organisms, it often acts as an essential growth factor in some bacterial species. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. Type Small Molecule Groups