Luciferase assay and ATAC-seq and ChIP-seq data show that Olig2-E1 is an OL-specific enhancer that is conserved across human, mouse and rat. Hi-C data reveal that Olig2-E1 physically interacts with OLIG2 and suggest that this interaction is specific to OL lineage cells.

OLIG2 is well known for determining motor neuron and oligodendrocyte differentiation, as well as its role in sustaining replication in early development. It is mainly involved in diseases such as brain tumor and Down syndrome.

As for the cortical layers, Olig2-AS are densely distributed in the layers 2–5, but are sparse in the layers 1 and 6 (Figures S2C1,C2). In contrast to the Olig2-AS distribution, GFAP-AS are preferentially localized to the sub-pial region (layer 1) and form the glia-limitans in all cortical areas (Figures 4C2–C5 , 5C1–C3 , Figures S2C3,C4 ).

Mar 17, 2022 · Here, we uncover a non-canonical function of OLIG2 in transcriptional repression to modulate myelinogenesis by functionally interacting with tri-methyltransferase SETDB1.

May 5, 2016 · Here, we find that the Brg1 subunit of SWI/SNF complexes interacts with a proximal Olig2 promoter and represses Olig2 transcription in the mouse cortex at E14, when oligodendrocyte progenitors (OPCs) are not yet found in this location.

Mar 10, 2011 · We show here that the proliferative function of Olig2 is controlled by developmentally regulated phosphorylation of a conserved triple serine motif within the amino-terminal domain.

Neural stem cells in the MGE express NKX2-1 and OLIG2. In intermediate progenitor cells, ASCL1 and DLX2 repress HES and OLIG2 expression and specify differentiation into GABAergic neurons. LHX6 expression and downregulation of NKX2-1 …

Our research has thus far concentrated on Olig2, a basic-helix-loop-helix (bHLH) transcription factor, by tracking the dynamics of Olig2-positive glial progenitor cells and the glial cells derived from them using the inducible CreER / loxP system for genetic marking.

In the cortex, most or all of the sparse OLIG2+ cells throughout the OSVZ and intermediate zone expressed NKX2-2. [...] GABAergic cortical interneurons underlie the complexity of neural circuits...

In this study, we developed a fluorescence-activated cell sorting (FACS)-based approach to purify Olig2-AS from other astrocyte populations as well as from oligo-dendroglial cells. We then used RNA sequencing (RNA-seq) to generate high-resolution transcriptome da-tabases and identify the molecular signature of the Olig2-AS.