Jan 1, 2016 · In the dermis, Sox2 is exclusively expressed in specialized mesenchymal cells that comprise the hair follicle dermal papilla during morphogenesis and throughout adulthood. Here we summarize our current understanding of Sox2 during development and maturation of skin, hair follicle regeneration, and cancer, and after cutaneous injury.

Sox2 in mesoderm development. During skin development, Sox2 is initially expressed in groups of mesenchymal cells called dermal condensates, that precede hair and whisker follicle formation and eventually give rise to the so-called dermal sheath and dermal papilla (DP)(Driskell et al., 2009; Rendl et al., 2005). The DP cyclically provides ...

Sep 9, 2014 · Thus, Sox2 is both a marker and a driver of stemness in skin SCC. Dirks and colleagues demonstrate that Sox2 is a marker of stemness by observing that Sox2 + cells are relatively quiescent, capable of self-renewal, differentiation, and …

SOX2 is a gene located on chromosome 3q26.33 that encodes a transcription factor important to maintenance of embryonic neural crest stem cell pluripotency. We have identified rare SOX2-immunoreactive cells in normal human skin at or near the established stem cell niches.

Jun 8, 2014 · Conditional Sox2 deletion in pre-existing skin papilloma and SCC leads to tumour regression and decreases the ability of cancer cells to be propagated upon transplantation into immunodeficient...

SOX2 is a gene located on chromosome 3q26.33 that encodes a transcription factor important to maintenance of embryonic neural crest stem cell pluripotency. We have identified rare SOX2-immunoreactive cells in normal human skin at or near the established stem cell niches.

Aim: This work aimed to evaluate the possible role of SOX2 in pathogenesis of non-melanoma skin cancer through its immunohistochemical assessment in BCC and SCC compared to normal skin and correlating its expression with the established prognostic factors.

Oct 1, 2013 · We conclude that Sox2 is a marker of two distinct lineages in the skin and regulates the number of differentiated cells in the case of the Merkel cell lineage and hair follicle type in the case of the DP.

Jan 1, 2016 · Here we summarize our current understanding of Sox2 during development and maturation of skin, hair follicle regeneration, and cancer, and after cutaneous injury.

Here we show that the transcription factor Sox2, which is not expressed in normal skin epithelium and is dispensable for epidermal homeostasis, marks tumor initiating cells (TICs) in cutaneous squamous cell carcinomas (SCC).