Jul 29, 2020 · In this review, we first briefly introduced SOX2 as a transcription factor, its domain structure, normal physiological functions, and its involvement in human cancers. We next …

SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem …

Sox2 is one of the key transcription factors that play an essential role in maintaining pluripotency of stem cells. Sox2 interacts with Oct4 to form a binary complex, which then recruits other …

SOX2 expression is activated through four main signaling pathways, including Shh, Wnt, FGFR and TGF-β . Shh pathway functions to induce cellular proliferation in the developing CNS and …

Similar to ESCs, Sox2 induces the expression of self-renewal pathways and inhibits the expression of differentiation genes in NPCs. Because Oct4 and other pluripotency-associated …

Sep 2, 2019 · Here we provide a comprehensive review of the current knowledge on SOX2 protein modifications, their proposed relationship to the PI3K/AKT pathway, and regulatory …

Jan 26, 2016 · SOX2 is a key regulator of multiple types of stem cells, especially embryonic stem cells (ESCs) and neural progenitor cells (NPCs). Understanding the mechanism underlying the …

An overview of the Sox2 signaling pathway, the functions of Sox2 and its implications in disease.

In most cancer types, SOX2 is a tumor-promoting factor that regulates tumor progression and metastasis primarily by maintaining the stemness of cancer cells. In addition, SOX2 also …

Apr 1, 2023 · Based on the SOX2 over-expression and knockdown technology, SOX2 was proved to be relevant to signal pathways directly through its targets or indirectly through its interacting …