SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem …

Sox2 is one of the key transcription factors that play an essential role in maintaining pluripotency of stem cells. Sox2 interacts with Oct4 to form a binary complex, which then recruits other …

Mar 30, 2025 · SOX2 (SRY-Box Transcription Factor 2) is a Protein Coding gene. Diseases associated with SOX2 include Microphthalmia, Syndromic 3 and Septooptic Dysplasia. Among …

Sep 2, 2019 · Here we provide a comprehensive review of the current knowledge on SOX2 protein modifications, their proposed relationship to the PI3K/AKT pathway, and regulatory …

Jul 29, 2020 · In this review, we first briefly introduced SOX2 as a transcription factor, its domain structure, normal physiological functions, and its involvement in human cancers. We next …

Mar 26, 2025 · Title: SOX2 represses c-MYC transcription by altering the co-activator landscape of the c-MYC super-enhancer and promoter regions. Secreted factors from M1 macrophages …

Jan 26, 2016 · We compared SOX2 global binding profiles, SOX2-regulated genes and SOX2 protein interactome between hESCs and hNPCs, and performed functional assays to test …

SRY-box transcription factor 2 (SOX2) is an intronless gene that produces a transcription factor that belongs to the SRY-related HMG-box (SOX) family that controls embryonic development …

The Sox2 transcription factor, encoded by a gene conserved in animal evolution, has become widely known because of its functional relevance for stem cells. In the developing nervous …

The SOX2 gene provides instructions for making a protein that plays a critical role in the formation of many different tissues and organs during embryonic development. Learn about this gene …