SOAT1 is a polytopic integral membrane protein belonging to the membrane-bound O-acyltransferase (MBOAT) superfamily. The structure of SOAT1 has not yet been solved but that of DltB, a bacterial MBOAT, suggests a complex arrangement of …

Mar 30, 2025 · SOAT1 (Sterol O-Acyltransferase 1) is a Protein Coding gene. Diseases associated with SOAT1 include Niemann-Pick Disease, Type C1 and Chronic Leukemia. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Statin inhibition of cholesterol production.

May 9, 2024 · Here we demonstrated that SOAT1 positively related to poor prognosis of HCC, EMT markers and promoted cell migration and invasion in vitro, which was mediated by the increased cholesterol in ...

Sep 7, 2020 · We identified sterol O-acyltransferase 1 (SOAT1) as a key player in sustaining the mevalonate pathway by converting cholesterol to inert cholesterol esters, thereby preventing the negative feedback elicited by unesterified cholesterol.

SOAT1 suppression might be a new therapeutic option in regard to targeting GBM growth and invasiveness. The higher expression in cells related to neuroinflammation compared to the tumor cells, could be of significance for a concomitant suppression of protumoral microglia/macrophages.

High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer. High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth. SOAT1 is a new prognostic factor of colorectal cancer.

Jun 22, 2018 · Sterol O-acyltransferase 1 (SOAT1) is a key enzyme for cholesteryl ester biosynthesis. The objective of the present study is to investigate the role and underlying molecular mechanisms of SOAT1 in atherosclerosis.

In this review, we mainly discuss the cholesterol metabolism centered on SOAT1 and mechanisms that regulate SOAT1 expression in cancers. Finally, the latest developments that target SOAT1 for cancer treatment are summarized.

May 18, 2020 · Sterol O-acyltransferase 1 (SOAT1, also named ACAT1) is an endoplasmic reticulum resident enzyme which catalyzes the esterification of cholesterol to generate cholesteryl esters.

May 18, 2020 · Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family. It catalyzes the esterification of cholesterol to …