snRNP s (pronounced "snurps"), or s mall n uclear r ibo n ucleo p roteins, are RNA - protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs.

We propose that inherent structural properties of this autoantigen complex, including common RNA-binding motifs, B and T-cell epitopes, and a unique stimulatory RNA molecule, underlie its susceptibility as a target of the autoimmune response.

Simple Network Management Protocol (SNMP) is an Internet Standard protocol for collecting and organizing information about managed devices on IP networks and for modifying that information to change device behavior. Devices that typically support SNMP include cable modems, routers, network switches, servers, workstations, printers, and more. [1]

Five small nuclear ribonucleoprotein particles (abbreviated to snRNPs) are involved in pre-mRNA splicing. Each snRNP contains a small nuclear RNA (snRNA) and a number of proteins. Each snRNP is named according to the snRNA it contains (ie, the U1, U2, U4, U5, and U6 snRNAs).

Jan 2, 2015 · We present two crystal structures of engineered U1 sub-structures, which together reveal at atomic resolution an almost complete network of protein–protein and RNA-protein interactions within U1 snRNP, and show how the 5′ splice site of …

Mar 1, 2011 · Each snRNP is a ribonucleoprotein complex consisting of an ‘snRNA’ (small nuclear RNA) and associated proteins. You might find these chapters and articles relevant to this topic.

Nov 25, 2021 · Recognition of the intron branch site (BS) by the U2 small nuclear ribonucleoprotein (snRNP) is a critical event during spliceosome assembly. In mammals, BS sequences are poorly conserved, and unambiguous intron recognition cannot be achieved solely through a base-pairing mechanism.

Jan 27, 2021 · In this review, we define the roles of different U5 snRNP proteins in RP, craniofacial disorders and cancer, including how disease-associated genetic variants affect pre-mRNA splicing and the proposed disease mechanisms.

Jun 17, 2021 · Eukaryotic cells can expand their coding ability by using their splicing machinery, spliceosome, to process precursor mRNA (pre-mRNA) into mature messenger RNA. The mega-macromolecular spliceosome...

Jul 14, 2015 · We uncover a stepwise and ordered formation of distinct Sm protein complexes on the PRMT5 complex, which is facilitated by the assembly chaperone pICln. Upon completion, the formed pICln-Sm units are displaced by new pICln-Sm …