Synaptosomal-Associated Protein, 25kDa (SNAP-25) is a Target Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein Receptor protein encoded by the SNAP25 gene found on chromosome 20p12.2 in humans.

Mar 30, 2025 · SNAP25 (Synaptosome Associated Protein 25) is a Protein Coding gene. Diseases associated with SNAP25 include Myasthenic Syndrome, Congenital, 18 and Presynaptic Congenital Myasthenic Syndromes. Among its related pathways are Neurotransmitter release cycle and Uptake and actions of bacterial toxins.

SNAP-25 is a component of the SNARE protein complex, which is involved in the exocytotic release of neurotransmitters during synaptic transmission. Through the coiled-coil assembly with syntaxin-1 and synaptobrevin, SNAP-25 mediates synaptic vesicle apposition to the presynaptic membrane permitting their Ca 2+ triggered fusion.

Neuron-derived exosomes-carried SNAP-25 could be an effective and accessible biomarker that reflects synapses integrity in the brain. The results show that overweight in boys with ADHD is associated with polymorphisms in SNAP25 , but not through conditioning deficits in …

SNAP25 is a part of the soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex which is critical for synaptic vesicle fusion in the presynaptic membrane, a key step in the release of neurotransmitters. SNAP25 is …

Nov 10, 2019 · SNAP-25 is regulated by alternative splicing, phosphorylation and by G-protein binding, and it regulates Ca 2+ -channels, neuronal survival and postsynaptic spine development.

HGNC Approved Gene Symbol: SNAP25. Intracellular vesicles travel among cellular compartments and deliver their specific cargo to target membranes by membrane fusion.

Feb 8, 2025 · Clinical resource with information about SNAP25, Common genetic variants associated with cognitive performance identified using the proxy-phenotype method., Congenital myasthenic syndrome 18, Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality., and available tests.

Jan 4, 2025 · SNAP25 disease mutations change the energy landscape for synaptic exocytosis due to aberrant SNARE interactions. SNAP-25, but not SNAP-23, is essential for photoreceptor development, survival, and function in mice.

SNAP25 is part of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein complex which is involved in exocytotic release of neurotransmitters. The gene SNAP25 provides the instruction for a protein that is located in synapses in the brain.