We show that GSK-3beta binds to and phosphorylates Snail at two consensus motifs to dually regulate the function of this protein. Phosphorylation of the first motif regulates its beta-Trcp-mediated ubiquitination, whereas phosphorylation of …

Sep 26, 2004 · We show that GSK-3β binds to and phosphorylates Snail at two consensus motifs to dually regulate the function of this protein. Phosphorylation of the first motif regulates its β-Trcp-mediated...

Snail not only acts primarily as a key inducer of EMT but also plays an important role in cell survival, immune regulation and stem cell biology. This review focuses on the regulation of Snail and discusses the EMT-dependent and -independent functions …

Oct 1, 2004 · A new mechanism in which GSK-3β phosphorylation regulates the rate of Snail protein degradation may provide insight into invasion and the metastatic progression of tumours.

Mechanistic study demonstrated that bFGF promoted the stability, nuclear localization and transcription of Snail by inhibiting the activity of glycogen synthase kinase 3 beta (GSK-3β) through phosphatidylinositide 3 kinases (PI3K)/protein kinase B (AKT) signaling pathway.

Oct 23, 2017 · In this study, we carried out a luciferase-based genome-wide screening using small interfering RNA library against ~200 of E3 ligases and ubiquitin-related genes and identified SOCS box protein...

Jan 1, 2005 · The combined abilities of GSK-3 to block Snail transcription, promote Snail degradation, and prevent Snail nuclear localization indicate that this kinase plays a central role in regulating Snail expression.

Jul 5, 2011 · The amount of Snail in cells is controlled by glycogen synthase kinase (GSK)-3β, which binds to and phosphorylates Snail in the nucleus and cytoplasm of cells and eventually leads to β-Trcp–mediated ubiquitination and subsequent proteasomal degradation of Snail (7).

Aug 16, 2014 · We propose a model in which EGF promotes the stabilization and transcription of Snail via the activation of PKC and subsequent inhibition of GSK-3β activity, which in turn decreases the ubiquitination of Snail and increases Snail transcription.

Aug 15, 2013 · Taken together, these results reveal that stabilization of Snail via AKT/GSK-3β signaling pathway is required for TNFα-induced EMT in prostate cancer cells. This study offers a better understanding of TNFα-induced metastasis and provides an effective therapeutic strategy for prostate cancer treatment.