SMG6 functions to bind single-stranded DNA in telomere maintenance and single-stranded RNA in nonsense-mediated mRNA decay (NMD). [10] [11] The SMG6 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease. [12]

Mar 30, 2025 · SMG6 (SMG6 Nonsense Mediated MRNA Decay Factor) is a Protein Coding gene. Diseases associated with SMG6 include Pancreatic Adenosquamous Carcinoma and Lissencephaly. Among its related pathways are Peptide chain elongation and Processing of Capped Intron-Containing Pre-mRNA.

Nov 30, 2021 · SMG6 is an endonuclease, which cleaves mRNAs during nonsense-mediated mRNA decay (NMD), thereby regulating gene expression and controling mRNA quality. SMG6 has been shown as a differentiation license factor of totipotent embryonic stem cells.

Nov 5, 2022 · SMG6 (also known as EST1A) functions in NMD, DNA repair, and telomere maintenance [26]. In the NMD pathway, SMG6 cooperates with other NMD core factors, such as UPF1 (DNA-RNA helicase)...

Jun 25, 2021 · Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly independent pathways, SMG6-mediated endonucleolytic cleavage and/or SMG5-SMG7-induced accelerated ...

Dec 7, 2008 · We identify the metazoan-specific NMD factor SMG6 as the responsible endonuclease by demonstrating that mutation of conserved residues in its nuclease domain—the C-terminal PIN motif—abolishes...

Feb 9, 2025 · SMG6 requires UPF1 and SMG1 for nonsense-mediated mRNA decay. The study demonstrates that SMG5-SMG7 and SMG6 exhibit different and non-overlapping modes of UPF1 recognition, thus pointing at distinguished roles in integrating the complex nonsense-mediated mRNA decay interaction network.

In contrast, the turnover of NMD substrates containing upstream ORFs and long 3' UTRs involves both SMG6- and SMG7-dependent endo- and exonucleolytic decay, respectively; extent to which SMG6 and SMG7 degrade NMD substrates is determined by the mRNA architecture.

Nov 11, 2022 · Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA turnover pathway that depends on the endonuclease SMG6. Here, we show that SMG6 is essential for male germ cell differentiation in mice.

Nov 27, 2014 · In this report, we describe the use of PARE to identify hundreds of endogenous SMG6 targets in human cells from the sequences of their cleavage products. Alignment of the cleavage sites revealed a pentameric motif favored by SMG6.