Mothers against decapentaplegic homolog 3 - Wikipedia
SMAD3-knockout mouse is a legitimate animal model of human aneurysms‐osteoarthritis syndrome (AOS), also named Loeys-Dietz Syndrome (type 3). SMAD3 deficiency promotes …
SMAD (protein) - Wikipedia
Smads (or SMADs) comprise a family of structurally similar proteins that are the main signal transducers for receptors of the transforming growth factor beta (TGF-B) superfamily, which …
SMAD3 Gene - GeneCards | SMAD3 Protein | SMAD3 Antibody
Mar 30, 2025 · SMAD3 (SMAD Family Member 3) is a Protein Coding gene. Diseases associated with SMAD3 include Loeys-Dietz Syndrome 3 and Familial Thoracic Aortic Aneurysm And …
SMAD3 gene - MedlinePlus
The SMAD3 gene provides instructions for making a protein involved in transmitting chemical signals from the cell surface to the nucleus. Learn about this gene and related health conditions.
SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory ...
SMAD3 knockdown significantly inhibits lung adenocarcinoma cell growth and increases radiosensitivity via P21. This suggests that SMAD3 is a potential prognostic and …
Roles of Smad3 in TGF-β Signaling During Carcinogenesis
Signaling of transforming growth factor β (TGF-β) is mediated through a heteromeric complex of two types of transmembrane receptors and downstream intracellular proteins known as …
Smad3 as a mediator of the fibrotic response - PMC
This review will focus on the role of Smad3, a mediator of TGF-β signalling, in regulating the fibrotic response, including discussions of Smad3-dependent gene regulation, its contribution …
SMAD3 SMAD family member 3 [ (human)] - National Center for ...
SMAD3 regulates transcription of MuRF-1 by increasing FoxO3 binding at a conserved FRE-SBE motif within the proximal promoter region, and by increasing FoxO3 protein content and …
SMAD3 SMAD family member 3 [ Homo sapiens (human) ]
Feb 20, 2025 · The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity …
Smad3 is essential for polarization of tumor-associated ... - Nature
Mar 31, 2023 · Here we examine TGF-β1/Smad3 signaling in tumor-associated neutrophils (TANs) in non-small cell lung carcinoma (NSCLC) patients. Smad3 activation in N2 TANs is …