Mar 30, 2025 · SLC7A5 (Solute Carrier Family 7 Member 5) is a Protein Coding gene. Diseases associated with SLC7A5 include Lysinuric Protein Intolerance and Autism Spectrum Disorder. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Blood-Brain Barrier: Anatomy.

Jan 7, 2021 · Nature Genetics - Colorectal tumors with mutated KRAS and APC require the amino acid transporter SLC7A5 to drive tumorigenesis. Mechanistically, SLC7A5 drives transcriptional and metabolic...

Jan 28, 2025 · SLC7A5 is an antiporter that can export glutamine, 40 and intracellular glutamine levels were increased in SLC7A5 KO cell lines in arginine-free media (Figures S2D and S2E). We next quantified the effects of SLC7A5 deletion on the total consumption of …

Jun 22, 2018 · SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide. The complex is responsible for uptake of essential amino acids in crucial body districts such as placenta and blood br …

Jun 21, 2018 · SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide. The complex is responsible for uptake of essential amino acids in crucial body districts such as placenta and blood brain barrier.

Mechanistically, SLC7A5 maintains intracellular amino acid levels following KRAS activation through transcriptional and metabolic reprogramming. This supports the increased demand for bulk protein synthesis that underpins the enhanced proliferation of KRAS-mutant cells.

Pharmacological inhibitionof SLC7A5 blocks growth under low-arginine conditions across a diverse group of cancer cell lines. Loss of SLC7A5 reduces tumor growth

Distinct from glucose transporters, amino acid transporters include ones whose expression is specific to cancer cells. For example, LAT1 (SLC7A5) displays protein expression mostly limited to the plasma membrane of cancer cells.

Study shows that the solute carrier transporter 7a5 (SLC7A5), a large neutral amino acid transporter localized at the blood brain barrier (BBB), has an essential role in maintaining normal levels of brain branched-chain amino acids; also identified several patients with autistic traits and motor delay carrying deleterious homozygous mutations ...

A parallel analysis in PHZ-treated ErGFPcre Slc7a5 LoxP/LoxP mice showed that - in contrast to baseline conditions (Figure 1B) - SLC3A2 surface expression was partially reduced in immature CD71 HI /Ter119 NEG/LOW and CD71 HI /Ter119 HI erythroblasts when compared with PHZ-treated control mice (Figure 2C, upper and middle right panels), which ...