Mar 30, 2025 · SLC1A5 (Solute Carrier Family 1 Member 5) is a Protein Coding gene. Diseases associated with SLC1A5 include Combined Oxidative Phosphorylation Deficiency 8 and Severe Nonproliferative Diabetic Retinopathy. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Signaling by Rho GTPases.

Sep 4, 2018 · SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family and localized in the plasma membrane of several body districts.

Solute linked carrier family 1 member A5 (SLC1A5) emerged as a top candidate. SLC1A5 acts as a high affinity transporter of L-glutamine (Gln) in rapidly growing epithelial and tumor cells in culture .

SLC1A5 co-expression with TALDO1 associates with endocrine therapy failure in estrogen receptor-positive breast cancer. A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells.

Feb 4, 2020 · Here, we show that the SLC1A5 variant plays a critical role in cancer metabolic reprogramming by transporting glutamine into mitochondria. The SLC1A5 variant has an N-terminal targeting signal for mitochondrial localization.

Oct 9, 2016 · Title: USP48 deubiquitination stabilizes SLC1A5 to inhibit retinal pigment epithelium cell inflammation, oxidative stress and ferroptosis in the progression of diabetic retinopathy. Radiation-induced exosomes promote oral squamous cell carcinoma progression via enhancing SLC1A5-glutamine metabolism.

Solute carrier family 1 member 5 (SLC1A5) is a member of the solute carrier (SLC) superfamily of transporters and plays an important role in tumors as a key transporter of glutamine into cells.

Sep 4, 2018 · SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family and localized in the plasma membrane of several body districts.

Feb 8, 2025 · Relationships between Slc1a5 and Osteoclastogenesis. Studies indicate a mechanism by which transcriptional enhancer factor 1 (TEAD1) promotes vascular smooth muscle cells (VSMCs) proliferation via transcriptional induction of …

Apr 19, 2021 · SLC1A5, the sodium dependent antiporter exchanges neutral amino acids (NAA) such as threonine, asparagine or serine for glutamine and the SLC3A2/SLC7A5 heterodimer exchanges glutamine for essential amino acids (EAAs), most importantly L-leucine.