Mar 30, 2025 · SLC19A1 (Solute Carrier Family 19 Member 1) is a Protein Coding gene. Diseases associated with SLC19A1 include Immunodeficiency 114, Folate-Responsive and Megaloblastic Anemia, Folate-Responsive. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Methotrexate Pathway, Pharmacokinetics.

Apr 2, 2025 · The solute carrier protein SLC19A1 is crucial for transporting folate nutrients, antifolate chemotherapeutics, and more recently cyclic dinucleotides (CDNs) immune transmitters, influencing ...

Oct 20, 2022 · Here we report cryo-electron microscopy structures of human SLC19A1 (hSLC19A1) in a substrate-free state and in complexes with multiple CDNs from different sources, a predominant natural folate...

Dec 28, 2022 · Here we report the cryo-EM structures of human SLC19A1 and its complex with 5-methyltetrahydrofolate at 3.5–3.6 Å resolution and elucidate the critical residues for substrate recognition.

The reduced folate carrier (RFC; SLC19A1) belongs to the solute carrier (SLC) group of transporters and is the principal mechanism by which folates and clinically used antifolates are delivered to mammalian cells and tissues from the systemic circulation at neutral pH …

Using a genome-wide CRISPR screen, we identified SLC19A1 as the first known importer of cGAMP and other CDNs, including the investigational new drug 2'3'-bisphosphosphothioate-cyclic-di-AMP (2'3'-CDA (S)).

Folate transporter 1 is a protein which in humans is encoded by the SLC19A1 gene. [ 5 ] Transport of folate compounds into mammalian cells can occur via receptor-mediated (see folate receptor 1) or carrier-mediated mechanisms.

Nov 15, 2023 · The SLC19A1 gene encodes reduced folate carrier-1 (RFC1), a transmembrane protein that facilitates the cellular uptake of anionic folates and folate analogs such as methotrexate (summary by Svaton et al., 2020).

Here we used a genome-wide CRISPR interference screen to identify the reduced folate carrier SLC19A1, a folate-organic phosphate antiporter, as the major transporter for CDNs. CDN uptake and functional responses are inhibited by depleting SLC19A1 from human cells and enhanced by overexpressing SLC19A1.

Jul 25, 2019 · Using a genome-wide CRISPR screen, we identified SLC19A1 as the first known importer of cGAMP and other CDNs, including the investigational new drug 2′3′-bisphosphosphothioate-cyclic-di-AMP (2′3′-CDA S).