Mar 30, 2025 · SLC16A1 (Solute Carrier Family 16 Member 1) is a Protein Coding gene. Diseases associated with SLC16A1 include Erythrocyte Lactate Transporter Defect and Hyperinsulinemic Hypoglycemia, Familial, 7 .

The solute carrier family 16 (SLC16) is comprised of 14 members of the monocarboxylate transporter (MCT) family that play an essential role in the transport of important cell nutrients and for cellular metabolism and pH regulation.

Monocarboxylate transporter 1 deficiency (MCTD1) is an autosomal dominant and recessive disease on the SLC16A1/MCT1 gene on chromosome 1p13.2. It causes poor feeding and vomiting, intellectual disability, ketotic hypoglycemia, ketoacidosis, ketonuria, with episodes brought on by fasting or infection.

The solute carrier family 16 (SLC16) is comprised of 14 members of the monocarboxylate transporter (MCT) family that play an essential role in the transport of important cell nutrients and for cellular metabolism and pH regulation.

The SLC16 gene family has fourteen members. Four (SLC16A1, SLC16A3, SLC16A7, and SLC16A8) encode monocarboxylate transporters (MCT1, MCT4, MCT2, and MCT3, respectively) catalysing the proton-linked transport of monocarboxylates such as l-lactate, pyruvate and ketone bodies across the plasma membrane …

Apr 7, 2025 · Title: Solute carrier transporter superfamily member SLC16A1 is a potential prognostic biomarker and associated with immune infiltration in skin cutaneous melanoma. The N-terminal signature motif on the transporter MCT1 is critical for CD147-mediated trafficking.

Feb 8, 2025 · Enables lactate transmembrane transporter activity. Involved in several processes, including plasma membrane lactate transport; pyruvate catabolic process; and regulation of insulin secretion. Located in plasma membrane. Is active in synapse.

Jan 1, 2021 · The focus of this review is to highlight novel structural insights obtained from X-ray structures of an L-lactate-transporting SLC16 family homolog. Furthermore, the roles of MCT1 (SLC16A1) and MCT4 (SLC16A3) in human disease (e.g., cancer metabolism and …

Our major findings for SLC16A1 regarding its participation in gene networks showed that SLC16A1 was a key controller of the cell cycle and mitosis, strongly suggesting its oncogene role in promoting cancer cell proliferation. SLC16A3 had a major effect on the metabolic process of pancreatic cancer.

Mutations in solute carrier family 16, member 1 (SLC16A1) gene. The SLC16A1 gene encodes the monocarboxylate transporter 1 (MCT1), which transports the monocarboxylates such as pyruvate and lactate into the cells.