A next-generation tumor-targeting IL-2 preferentially promotes …
Aug 28, 2019 · We propose that lack of IL-2 limits the proper expansion of antigen-specific T cells (SIY-reactive T cells in the B16-SIY model and OVA-reactive T cells in MC38-OVA model), …
Regulated expression of a tumor-associated antigen reveals …
We have shown that SIY-reactive T cells can be functionally activated in tumor-bearing R26LSL-LSIY/+ mice, but as these cells are short-lived, T cell death remains an obstacle to effective …
Intratumoral CD8+ T-Cell Apoptosis is a Major Component of T …
The SIY peptide is presented to CD8 + T cells in the context of H2-K b (10), which enables monitoring of SIY-specific T cell responses in tumor-bearing hosts using IFN-γ ELISPOT, as …
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Cell | 肿瘤中的亚优势抗原决定TCF1+CD8+T前体细胞的表型 - 知乎
Oct 20, 2021 · 首先，作者构建了连接荧光素酶报告基因的SIIN（SIINFEKL）和SIY（SIYRYYGL）两种CD8+T细胞新抗原，并且以此为基础建立了表达这些肿瘤特异性新抗 …
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Tumor cure by radiation therapy and checkpoint inhibitors
May 3, 2018 · We demonstrate that blocking immune responses at tumor implantation blocks development of a tumor-resident antigen specific T cell population and prevents tumor cure by …
Persistence of tumor-infiltrating CD8 T cells is tumor ... - PubMed
We have previously developed a modified TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model where prostate cancer cells express the T-cell epitope SIYRYYGL (SIY) …
Anti-Peptide SIY (SIYRGYYL) T Cell Receptor (2C), Jurkat Cell Line ...
The anti-Peptide SIY (SIYRGYYL) TCR Jurkat cell line is a stable cell line made from the anti-Peptide SIY TCR lentivirus. The recombinant Jurkat T cell was designed to predict the MOA of …
- Reviews: 1
Anti-Peptide SIY T cell receptor (2C), pCDTCR1 (TCR-YC0959)
2C TCR recognizes two structurally distinct ligands, SIY-K (b) and alloantigen QL9-L (d). The ability of a single TCR to cross-react with different pMHC (sometimes called TCR degeneracy) …
- Reviews: 1
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