Jan 25, 2021 · We examined in more detail the course of the arc-shaped Sim1 -expressing NLOT2ms/CAS using Tbr1 immunoreaction and Dlx5 ISH, which respectively mark the pallium versus subpallium domains.

Mixed with its Tbr1-expressing layer 2 pyramidal cell population (NLOT2), there are Sim1-expressing cells whose embryonic origin and mode of arrival remain unclear. We examined this population with Sim1-ISH and a Sim1-tauLacZ mouse line. An alar hypothalamic origin is apparent at the paraventricular area, which expresses Sim1 precociously.

Oct 12, 2023 · Quantitative mapping of GABAergic types with single-molecule FISH (smFISH) reveals that interneurons in the striatum and neocortex follow distinct spatial principles, and that lateral prefrontal and other higher-order cortical association areas are distinguished by high proportions of VIP+ neurons.

Mixed with its Tbr1-expressing layer 2 pyramidal cell population (NLOT2), there are Sim1-expressing cells whose embryonic origin and mode of arrival remain unclear. We examined this population...

To study the molecular pathways by which Sim1 and Arnt2 control the development of the hypothalamic secretory neurons and mediate energy homeostasis, we combined an inducible gene expression system with microarray analysis to screen for their downstream targets.

SIM is a basic helix-loop-helix – PAS domain transcription factor that regulates gene expression in the midline cells.

May 1, 2007 · SIM1 is a transcription factor essential for the developmental expression of the endocrine hormone genes, e. g. vasopressin ( Vp) and oxytocin ( Ot ), in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus.

SIM1 is a transcription factor essential for the developmental expression of the endocrine hormone genes, e.g. vasopressin (Vp) and oxytocin (Ot), in the paraventricular nucleus (PVN) and...

Jan 25, 2021 · We examined in more detail the course of the arc-shaped Sim1 -expressing NLOT2ms/CAS using Tbr1 immunoreaction and Dlx5 ISH, which respectively mark the pallium versus subpallium domains.

Single-minded 1 (SIM1) is a basic helix-loop-helix transcription factor involved in the development and function of the paraventricular nucleus of the hypothalamus. Obesity has been reported in Sim1 haploinsufficient mice and in a patient with a balanced translocation disrupting SIM1.