Mar 30, 2023 · A nuclear-encoded sigma factor integrates low-temperature and circadian signals, contributing to photosynthetic resilience to long-term cold.

Dec 8, 2021 · Nature - Crystal structures of the σ2 receptor are determined and used to perform a docking screen of nearly 500 million molecules, identifying σ2-selective ligands and providing insight...

Apr 4, 2016 · Here we report crystal structures of the human σ 1 receptor in complex with two chemically divergent ligands, PD144418 and 4-IBP. The structures reveal a trimeric architecture with a single...

Here we determined the crystal structure of this receptor in complex with the clinical candidate roluperidone 2 and the tool compound PB28 8. These structures templated a large-scale docking screen of 490 million virtual molecules, of which 484 compounds were synthesized and tested.

The fifteen articles included in this collection provide a wide overview of the most urgent questions regarding sigma-1 and sigma-2 receptors in terms of their chemistry, pharmacology, and therapeutic indications.

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Dec 14, 2023 · Sigma-1 receptor (S1R) is a unique multi-tasking chaperone protein in the endoplasmic reticulum. Since S1R agonists exhibit potent antidepressant-like activity, S1R has become a novel target...

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Jul 7, 2021 · The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in Sigmar1 have been identified as a causative gene …