Jun 23, 2018 · Rac1 aggravates the damage of myocardial cells in the process of myocardial ischemia-reperfusion during myocardial infarction through activating the NADPH oxidase and bringing about the reactive oxygen species (ROS) generation.

At present, there was no research on the relationship between Rac1 and chemoresistance in HCC. We explored the effect of sorafenib on si-Rac1 or Rac1-transfected HCC cells using the MTT assay. Si-Rac1 prevented sorafenib resistance of hep3B and Huh7 cells than si-NC transfection (Figure 4(a)).

Abnormal Rac1 signaling is linked to a number of debilitating human diseases, including cancer, cardiovascular diseases and neurodegenerative disorders. As such, Rac1 represents an attractive therapeutic target, yet the search for effective Rac1 inhibitors is still underway.

RAC1 demonstrated strong diagnostic potential and was associated with advancing clinical stages and poor prognosis. RAC1 expression was linked to genomic alterations, immune checkpoint activity, and reduced B cell infiltration, suggesting its role in shaping the tumor microenvironment.

Jan 1, 2019 · Subtomogram averaging of 2,098 ribosomes detected in regions of low Rac1 activity (SI Appendix, Fig. S7A) yielded a resolution estimate of about 3 nm to 4 nm (SI Appendix, Fig. S7C), providing a measure for the tentative resolution of the cryo-ET reconstructions.

Rac1, a member of the Rho family of guano-sine triphosphatases, exists in 2 conformational states, an inactive GDP-bound state and an active GTP-bound state.

Apr 1, 2017 · As a member of the Rho family of guanosine triphosphatases, Rac1 is an important regulator of osteoblast functions. However, little is known about its role in regenerative endodontic procedures. The current study examined the role of Rac1 in the proliferation, migration, and odontoblastic differentiation of MDPC-23 cells.

Sep 1, 2023 · In conclusion, interference with Rac1 and Prex1 could inhibit MGC-803 and MKN45 cells EMT, promote apoptosis, and upregulate PDLIM2 expression. The Rac1 and Prex1 play crucial roles in cancer cells. This study provided new ideas and approaches for the treatment of EMT-related diseases.

Nov 1, 2023 · The activity of Rac1 was detected by pull-down and Western blot tests. Viral-mediated gene transfer of Rac1 was used to investigate its role in ELS-induced depression-like behaviors in adolescence.

Rac1, known as a “molecular switch”, plays a crucial role in plenty of cellular processes. Rac1 aggravates the damage of myocardial cells in the process of myocardial ischemia-reperfusion...