Inositol phospholipid signaling pathways have begun to emerge as important players in stem cell biology and bone marrow transplantation [ 1 – 4 ]. The SH2-containing Inositol Phosphatase (SHIP) is among the enzymes that can modify endogenous mammalian phosphoinositides.

In this study, we report the identification of a chemical inhibitor of SHIP1, 3 α-aminocholestane (3AC). Treatment with 3AC significantly expands the myeloid immunoregulatory cell compartment and impairs the ability of peripheral lymphoid tissues to prime allogeneic T cell responses.

The phosphoinositide phosphatase SHIP is a critical regulator of immune cell activation. Despite considerable study, the mechanisms controlling SHIP activity to ensure balanced cell activation rema...

SHIP1 is at the nexus of intracellular signaling pathways in immune cells that mediate BM graft rejection, production of inflammatory and immunosuppressive cytokines, immunoregulatory cell formation, the BM niche that supports development of the immune system and immune cancers.

Inositol phospholipid signaling pathways have begun to emerge as important players in stem cell biology and bone marrow transplantation [1-4]. The SH2-containing Inositol Phosphatase (SHIP) is among the enzymes that can modify endogenous mammalian phosphoinositides.

In recent years a new signaling protein component of many growth factor receptor signaling pathways has been identified, called SHIP (SH 2-containing I nositol 5′- P hosphatase). This review presents current structural information on the …

SHIP (cytoplasmic SHIP) is the complete murine SHIP protein, which contains an N-terminal SH2 domain, a 5′-phosphoinositol phosphatase domain (5′-IPase), two PTB binding site motifs (Y Y), and a proline-rich domain (Pro).

Nov 11, 2002 · We show that in haematopoietic cells, TGF-β family members regulate apoptosis through expression of the inositol phosphatase SHIP (Src homology 2 (SH2) domain-containing 5′ inositol phosphatase),...

In recent years a new signaling protein component of many growth factor receptor signaling pathways has been identified, called SHIP (SH 2-containing I nositol 5′-P hosphatase). This review presents current structural information on the …

In recent years a new signaling protein component of many growth factor receptor signaling pathways has been identified, called SHIP (SH2-containing Inositol 58-Phosphatase). This re- view presents current structural information on the SHIP protein and its …