My research involves yeast and human cell lines, and I identified Rif1-mediated Protein Phosphatase 1 (PP1) targeting to replication initiation proteins. I showed that RIF1-PP1 controls the initiation of DNA replication by modulating the phosphorylation status of …

S Hiraga, T Ly, J Garzón, Z Hořejší, Y Ohkubo, A Endo, C Obuse, ... KN Klein, PA Zhao, X Lyu, T Sasaki, DA Bartlett, AM Singh, I Tasan, ... The DNA polymerase domain of polε is required...

Sensory circuit reorganization via microglia causes the development of post-stroke pain. The role of microglia in chronic pain after stroke in mouse. researchmapは、日本の研究者情報を収集・公開するとともに、研究者等による情報発信の場や研究者等の間の情報交換の場を提供することを目的として、国立研究開発法人科学技術振興機構（JST）が運営するサービスです。

RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing. During repair of DNA double-strand breaks (DSBs), RIF1 functions in the 53BP1-Shieldin pathway that...

Shin-Ichiro HIRAGA, Postdoctoral researcher | Cited by 47 | | Read 6 publications | Contact Shin-Ichiro HIRAGA

Quantitative proteomic analysis of chromatin reveals that Ctf18 acts in the DNA replication checkpoint. Contributors: Lian, H.-Y.; Robertson, E.D.; Hiraga, S.- I.; Alvino, G.M.; Collingwood, D.; McCune, H.J.; Sridhar, A.; Brewer, B.J.; Raghuraman, M.K.; Donaldson, A.D.

Shin-ichiro Hiraga, Takahide Itokazu, Mariko Nishibe, Toshihide Yamashita Inflammation and Regeneration, 42(15) 1-10, May, 2022 Peer-reviewed Invited Lead author Synaptic and Genetic Bases of Impaired Motor Learning Associated with Modified Experience-Dependent Cortical Plasticity in Heterozygous Reeler Mutants

Feb 13, 2020 · Here, we established a CPSP mouse model by inducing a focal hemorrhage in the thalamic ventrobasal complex and confirmed the development of mechanical allodynia. In this model, microglial activation was observed in the somatosensory cortex, as …

My research involves yeast and human cell lines, and I identified Rif1-mediated Protein Phosphatase 1 (PP1) targeting to replication initiation proteins. I showed that RIF1-PP1 controls the initiation of DNA replication by modulating the phosphorylation status of …

May 3, 2022 · We herein highlight the mechanisms underlying neuroplasticity that occur in the somatosensory circuit of the spinal dorsal horn, thalamus, and cortex associated with chronic pain following injury to the peripheral nervous system (PNS) or CNS. We also discuss the dynamic functions of microglia in shaping neuroplasticity related to chronic pain.