PU.1 can modulate the expression of 3000 genes in hematopoietic cells including cytokines. It is expressed in monocytes, granulocytes, B and NK cells but is absent in T cells, reticulocytes …

Jul 30, 2009 · We used immortalized Gata1 (-) erythromegakaryocytic progenitor cells to study how PU.1/Sfpi1 expression is regulated by GATA-1 and GATA-2, a related factor that is …

Jul 30, 2009 · To investigate whether GATA-1 represses transcription of PU.1/Sfpi1 directly, we investigated whether functionally important GATA binding motifs are present in the PU.1/Sfpi1 …

Nov 1, 2007 · Transcriptome profiling of purified preparations evidenced the preferential accumulation in SSCs of transcripts of PU.1(Sfpi1), a regulatory gene previously identified in …

Jul 7, 2009 · GATA-2 deficiency induces PU-1/Sfpi1 and reprograms G1ME cells to macrophages. (A) Relative expression of Gata2 and selected myeloid and macrophage-specific target genes …

Jan 9, 2012 · The proto-oncogene PU.1, upregulated in virally induced erythroleukemias, is an Ets family transcription factor encoded by the Sfpi1/Spi-1 gene. 1 PU.1 has critical roles in …

Jan 15, 2009 · Red pulp macrophages are a distinct splenic subset involved in removing senescent red blood cells. Transcription factors such as PU.1 (also known as Sfpi1) and …

Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable …

Oct 16, 2009 · The transcription factor PU.1, encoded by the Sfpi1 gene, functions in a graded manner to regulate macrophage versus B cell generation; its higher concentration favors the …

Here we showed that PU.1 (encoded by Sfpi1) was essential for dendritic cell (DC) development in vivo and that conditional ablation of PU.1 in defined precursors, including the common DC …