SET/PP2A signaling regulates macrophage positioning in hypoxic …
Oct 12, 2022 · We demonstrate that in response to a hypoxic environmental cue, SET translocates to the cytoplasm through the protein kinase C (PKC)-casein kinase 2α (CK2α) signaling axis and regulates...
SET-PP2A complex as a new therapeutic target in KMT2A (MLL
Oct 27, 2023 · In this study we uncover the essential role and underlying mechanisms of SET, the endogenous inhibitor of Ser/Thr phosphatase PP2A, in KMT2A -R-leukemia.
PP2A complex disruptor SET prompts widespread ... - Science
Jan 26, 2024 · Through blocking PP2A activity, SET assisted CDK9 to maintain Pol II CTD phosphorylation and activated mRNA transcription. Our findings position SET as a key factor that modulates chromatin PP2A activity, promoting the oncogenic transcription in the …
A new regulatory mechanism of protein phosphatase 2A activity via SET ...
Jan 8, 2020 · We provide evidence that p38β potentiates SET-mediated PP2A inactivation by two mechanisms: facilitating SET cytoplasmic translocation through CK2 phosphorylation, and directly binding to and...
The interaction of SET and protein phosphatase 2A as target
Disruption of the interaction between SET and PP2A to rescue the activity of PP2A may represent a new therapeutic strategy and opportunity for cancer treatment. This review brings up-to-date advances on the interactions between SET and PP2A and their biological consequences.
SET-PP2A complex as a new therapeutic target in KMT2A (MLL) …
In this study we uncover the essential role and underlying mechanisms of SET, the endogenous inhibitor of Ser/Thr phosphatase PP2A, in KMT2A -R-leukemia.
SET-PP2A complex as a new therapeutic target in KMT2A (MLL
Oct 27, 2023 · In this study we uncover the essential role and underlying mechanisms of SET, the endogenous inhibitor of Ser/Thr phosphatase PP2A, in KMT2A-R-leukemia.
The interaction of SET and protein phosphatase 2A as target …
Aug 1, 2021 · This review brings up-to-date advances on the interactions between SET and PP2A and their biological consequences. Moreover, we review reported inhibitors of SET-PP2A interaction under investigation as therapeutic opportunities for the treatment of cancers.
Targeting PP2A in cancer: Combination therapies - PMC
In addition to the core PP2A protein subunits, endogenous regulatory proteins for PP2A (e.g. CIP2A, SET, PME-1) provide further points of pharmacologic targeting to modulate PP2A function. PP2A is functionally impaired in cancer through inactivating mutations, suppression of individual subunits and up-regulation of endogenous regulators [ 15 ...
Therapeutic Targeting of PP2A - PMC - PubMed Central (PMC)
Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase that regulates many cellular processes. Given the central role of PP2A in regulating diverse biological functions and its dysregulation in many diseases, including cancer, PP2A directed therapeutics have …